PMID- 24806356
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150116
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 95
IP  - 2
DP  - 2015 Feb
TI  - Lichen planopilaris is associated with HLA DRB1*11 and DQB1*03 alleles.
PG  - 177-80
LID - 10.2340/00015555-1884 [doi]
AB  - There are no studies of the possible association of the human leukocyte antigen 
      (HLA) system with lichen planopilaris (LPP). To determine whether the HLA system 
      is associated with LPP, 40 consecutive Jewish Israeli patients with LPP (study 
      group) and 252 volunteers (controls) were typed for DRB1*and DQB1* loci by 
      molecular methods. Compared with controls, the study group had a significantly 
      higher frequency of the DRB1*11 allele (62% vs. 21%, corrected p-value 
      (pc) = 0.001) owing to increased frequencies of DRB1*11: 01 and DRB1*11: 04. The 
      DQB1*03 allele was also expressed at a significantly higher frequency in the 
      study group (70% vs. 33%, pc = 0.0005); specifically, the frequency of DQB1*03: 
      01 was increased. The majority (82.5%) of the patients were of non-Ashkenazi 
      origin. We conclude that LPP appears to be over-represented in non-Ashkenazi 
      Jewish patients and is associated with an increased frequency of HLA DRB1*11 and 
      DQB1*03 alleles. These findings suggest that immunogenetic factors play a role in 
      LPP.
FAU - Pavlovsky, Lev
AU  - Pavlovsky L
AD  - Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petah Tikva 
      49100, Israel.
FAU - Israeli, Moshe
AU  - Israeli M
FAU - Sagy, Eti
AU  - Sagy E
FAU - Berg, Amy L
AU  - Berg AL
FAU - David, Michael
AU  - David M
FAU - Shemer, Avner
AU  - Shemer A
FAU - Klein, Tirza
AU  - Klein T
FAU - Hodak, Emmilia
AU  - Hodak E
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*11 antigen)
RN  - Lichen planus follicularis
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Israel/epidemiology
MH  - Jews/genetics
MH  - Lichen Planus/diagnosis/ethnology/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Risk Factors
EDAT- 2014/05/09 06:00
MHDA- 2015/09/22 06:00
CRDT- 2014/05/09 06:00
PHST- 2014/05/09 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - 10.2340/00015555-1884 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2015 Feb;95(2):177-80. doi: 10.2340/00015555-1884.