PMID- 2480702
OWN - NLM
STAT- MEDLINE
DCOM- 19900125
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 28
IP  - 3-4
DP  - 1989 Nov
TI  - Kinetics of histamine released from rectal mucosa.
PG  - 164-7
AB  - This kinetic study was performed to investigate the different tissue-influencing 
      histamine amounts in Crohn's Disease (CD), Ulcerative Colitis (UC), patients with 
      polyps and cancers (P.a.C.Gr) and in a Control Group (CG). For this purpose the 
      endoscopically obtained specimens from rectal mucosa were immediately placed into 
      1000 microliters of Hank's incubation medium in order to determine the 
      spontaneously released histamine amounts at the time points of 5, 10, 15, 20 and 
      30 minutes. Each time a volume of 100 microliters was removed from the incubation 
      medium and the kinetic value (KV) was detected by using the single isotope 
      radioenzymatic method. Influencing of natural histamine catabolism and the 
      comparison of the tissue histamine release with or without air oxygen in the 
      incubation medium using four kinetic programmes (KP1-4) provides clearly 
      different KVs, not only between the KPs but also within the same KP. The 
      P.a.C.Gr. shows higher kinetic values (KVs) compared with the CG. In KP1-3 the 
      kinetic courses (KCs) of the Inflammatory Bowel Diseases (IBDs), CD and UC-both 
      not yet divided in active (a.) or not active (n.a.) disease stages-cross the KCs 
      of the CG several times. Only the differentiation of the IBDs in active and not 
      active disease stages in KP4 reveals that CDa. and UCa. stand out from the CG by 
      higher KVs, and in contrast, CDn.a. and UCn.a. have lower KVs than the CG. The 
      released amounts of histamine in CDa. and UCa. are significantly higher than in 
      CDn.a. and UCn.a.
FAU - Raithel, M
AU  - Raithel M
AD  - Institute of Clinical Immunology, University of Erlangen-Nurnberg, FRG.
FAU - Horauf, A M
AU  - Horauf AM
FAU - Matek, M
AU  - Matek M
FAU - Baenkler, H W
AU  - Baenkler HW
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
SB  - IM
MH  - Adult
MH  - Aged
MH  - Colitis, Ulcerative/metabolism
MH  - Crohn Disease/metabolism
MH  - Female
MH  - *Histamine Release
MH  - Humans
MH  - In Vitro Techniques
MH  - Intestinal Mucosa/*metabolism
MH  - Intestinal Polyps/metabolism
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Rectal Neoplasms/metabolism
MH  - Rectum/metabolism
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1007/BF01967396 [doi]
PST - ppublish
SO  - Agents Actions. 1989 Nov;28(3-4):164-7. doi: 10.1007/BF01967396.