PMID- 24807589
OWN - NLM
STAT- MEDLINE
DCOM- 20160317
LR  - 20211021
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 30
IP  - 1
DP  - 2015 Feb
TI  - The effect of curcumin on the brain-gut axis in rat model of irritable bowel 
      syndrome: involvement of 5-HT-dependent signaling.
PG  - 47-55
LID - 10.1007/s11011-014-9554-z [doi]
AB  - Irritable bowel syndrome (IBS) is induced by dysfunction of central nervous and 
      peripheral intestinal systems, which affects an estimated 10-15% population 
      worldwide annually. Stress-related psychiatric disorders including depression and 
      anxiety are often comorbid with gastrointestinal function disorder, such as IBS. 
      However, the mechanism of IBS still remains unknown. Curcumin is a biologically 
      active phytochemical presents in turmeric and has pharmacological actions that 
      benefit patients with depression and anxiety. Our study found that IBS rats 
      showed depression- and anxiety-like behaviors associated with decreased 5-HT 
      (serotonin), BDNF (Brain-derived neurotrophic factor) and pCREB (phosphorylation 
      of cAMP response element-binding protein) expression in the hippocampus after 
      chronic acute combining stress (CAS). However, these decreased parameters were 
      obviously increased in the colonic after CAS. Curcumin (40 mg/kg) reduced the 
      immobility time of forced swimming and the number of buried marbles in behavioral 
      tests of CAS rats. Curcumin also decreased the number of fecal output and 
      abdominal withdrawal reflex (AWR) scores in response to graded distention. 
      Moreover, curcumin increased serotonin, BDNF and pCREB levels in the hippocampus, 
      but they were decreased in the colonic of CAS rats. 5-HT(1A) receptor antagonist 
      NAN-190 reversed the effects of curcumin on behaviors and the changes of 
      intestine, pCREB and BDNF expression, which are related to IBS. These results 
      suggested that curcumin exerts the effects on IBS through regulating 
      neurotransmitters, BDNF and CREB signaling both in the brain and peripheral 
      intestinal system.
FAU - Yu, Yingcong
AU  - Yu Y
AD  - Department of Gastroenterology, Wenzhou No.3 Clinical Institute of Wenzhou 
      Medical University, Wenzhou people's hospital, Wenzhou, Zhejiang Province, 
      325000, China.
FAU - Wu, Shujuan
AU  - Wu S
FAU - Li, Jianxin
AU  - Li J
FAU - Wang, Renye
AU  - Wang R
FAU - Xie, Xupei
AU  - Xie X
FAU - Yu, Xuefeng
AU  - Yu X
FAU - Pan, Jianchun
AU  - Pan J
FAU - Xu, Ying
AU  - Xu Y
FAU - Zheng, Liang
AU  - Zheng L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140508
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Piperazines)
RN  - 0 (Serotonin 5-HT1 Receptor Antagonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 115338-32-4 (1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine)
RN  - 333DO1RDJY (Serotonin)
RN  - IT942ZTH98 (Curcumin)
RN  - OGG85SX4E4 (Imipramine)
RN  - Q3JTX2Q7TU (Diazepam)
SB  - IM
MH  - Animals
MH  - Anxiety/drug therapy/physiopathology
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Colon/metabolism
MH  - Curcumin/pharmacology/*therapeutic use
MH  - Cyclic AMP Response Element-Binding Protein/biosynthesis
MH  - Defecation
MH  - Diazepam/pharmacology
MH  - Disease Models, Animal
MH  - Drug Evaluation, Preclinical
MH  - Enteric Nervous System/*physiopathology
MH  - Gastrointestinal Motility/drug effects
MH  - Hippocampus/metabolism/*physiopathology
MH  - Imipramine/pharmacology
MH  - Irritable Bowel Syndrome/*drug therapy/physiopathology
MH  - Male
MH  - Phosphorylation
MH  - Physical Exertion
MH  - Piperazines/pharmacology
MH  - Pressure/adverse effects
MH  - Protein Processing, Post-Translational
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/biosynthesis/drug effects/physiology
MH  - Serotonin/biosynthesis/*physiology
MH  - Serotonin 5-HT1 Receptor Antagonists/pharmacology
MH  - Signal Transduction
MH  - Stress, Physiological/physiology
MH  - Stress, Psychological/physiopathology
MH  - Up-Regulation/drug effects
EDAT- 2014/05/09 06:00
MHDA- 2016/03/18 06:00
CRDT- 2014/05/09 06:00
PHST- 2014/03/07 00:00 [received]
PHST- 2014/04/22 00:00 [accepted]
PHST- 2014/05/09 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2016/03/18 06:00 [medline]
AID - 10.1007/s11011-014-9554-z [doi]
PST - ppublish
SO  - Metab Brain Dis. 2015 Feb;30(1):47-55. doi: 10.1007/s11011-014-9554-z. Epub 2014 
      May 8.