PMID- 24809340
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 5
DP  - 2014
TI  - Leukocyte mitochondrial DNA copy number in blood is not associated with major 
      depressive disorder in young adults.
PG  - e96869
LID - 10.1371/journal.pone.0096869 [doi]
LID - e96869
AB  - BACKGROUND: Major depressive disorder (MDD) is the leading cause of disability 
      worldwide, and has significant genetic predisposition. Mitochondria may have a 
      role in MDD and so mitochondrial DNA (mtDNA) has been suggested as a possible 
      biomarker for this disease. We aimed to test whether the mtDNA copy number of 
      peripheral blood leukocytes is related to MDD in young adults. METHODS: A 
      case-control study was conducted with 210 MDD patients and 217 healthy controls 
      (HC). The mtDNA copy number was measured by quantitative polymerase chain 
      reaction (qPCR) method. Depression severity was assessed by the Hamilton-17 
      Depression Rating Scale (HDRS-17). RESULTS: We found no significant differences 
      in mtDNA copy number between MDD patients and HC, though the power analysis 
      showed that our sample size has enough power to detect the difference. There were 
      also no significant correlations between mtDNA copy number and the clinical 
      characteristics (such as age, age of onset, episodes, Hamilton Depression Rating 
      Scale (HDRS) score and Global Assessment of Function Scale (GAF) score) in MDD 
      patients. CONCLUSION: Our study suggests that leukocyte mtDNA copy number is 
      unlikely to contribute to MDD, but it doesn't mean that we can exclude the 
      possibility of involvement of mitochondria in the disease. Further studies are 
      required to elucidate whether mtDNA can be a biomarker of MDD.
FAU - He, Ying
AU  - He Y
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Tang, Jinsong
AU  - Tang J
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Li, Zongchang
AU  - Li Z
AD  - Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 
      China.
FAU - Li, Hong
AU  - Li H
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Liao, Yanhui
AU  - Liao Y
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Tang, Yanqing
AU  - Tang Y
AD  - Department of Psychiatry, First Affiliated Hospital, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Tan, Liwen
AU  - Tan L
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Xia, Kun
AU  - Xia K
AD  - The State Key Laboratory of Medical Genetics, Central South University, Changsha, 
      Hunan, China.
FAU - Chen, Xiaogang
AU  - Chen X
AD  - Institute of Mental Health, the Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China; The State Key Laboratory of Medical Genetics, 
      Central South University, Changsha, Hunan, China; Key Laboratory of Psychiatry 
      and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 
      China; The State Key Laboratory of Medical Genetics, Central South University, 
      Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140508
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - DNA, Mitochondrial/*blood/*genetics
MH  - Depressive Disorder, Major/*blood/*genetics
MH  - Female
MH  - *Gene Dosage
MH  - Humans
MH  - Leukocytes/*metabolism
MH  - Male
MH  - Young Adult
PMC - PMC4014566
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/05/09 06:00
MHDA- 2015/01/23 06:00
PMCR- 2014/05/08
CRDT- 2014/05/10 06:00
PHST- 2013/12/30 00:00 [received]
PHST- 2014/04/12 00:00 [accepted]
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PHST- 2014/05/08 00:00 [pmc-release]
AID - PONE-D-13-54935 [pii]
AID - 10.1371/journal.pone.0096869 [doi]
PST - epublish
SO  - PLoS One. 2014 May 8;9(5):e96869. doi: 10.1371/journal.pone.0096869. eCollection 
      2014.