PMID- 24810146
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20220409
IS  - 1878-0210 (Electronic)
IS  - 1878-0210 (Linking)
VI  - 9
IP  - 1
DP  - 2015 Feb
TI  - Meta-analysis of Atherogenic Index of Plasma and other lipid parameters in 
      relation to risk of type 2 diabetes mellitus.
PG  - 60-7
LID - S1751-9918(14)00044-8 [pii]
LID - 10.1016/j.pcd.2014.03.007 [doi]
AB  - AIMS: Diabetic dyslipidemia is one of important complication of type 2 diabetes 
      mellitus (T2DM). Blood lipid parameters (e.g., triglyceride, TG; total 
      cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; low-density 
      lipoprotein cholesterol, LDL-C; Atherogenic Index of Plasma defined as 
      lg(TG/HDL-C), AIP), are important indexes in predicting risk of T2DM. This study 
      performed comprehensive meta-analyses to evaluate the powers of these indexes, 
      especially for AIP, on predicting risk of T2DM. METHODS: We searched PubMed 
      Database, China National Knowledge Infrastructure (CNKI) and Wanfang Database in 
      February 2014 to identify eligible studies. Case-control studies that have mean 
      baseline values of AIP were included. Random-effect models were used to pool the 
      summary standardized mean difference (SMD) in meta-analysis. RESULTS: Fifteen 
      eligible studies, with a total sample size of 4010, were included in 
      meta-analysis. All these studies reported positive associations between AIP and 
      T2DM. Moreover, the SMD for the AIP is 1.78 (95% confidence interval (CI): 
      1.04-2.52), which is higher than for other parameters (TG: 0.93, 95% CI: 
      0.78-1.09; TC: 0.46, 95% CI: 0.21-0.71; HDL-C: -0.89, 95% CI: -1.18 to -0.60; and 
      LDL-C: 0.44, 95% CI: 0.11-0.77). Meta-analysis of association between BMI and 
      T2DM gave a SMD of 0.85 (95% CI: 0.38 to 1.32). CONCLUSIONS: The results suggest 
      that lipid parameters have ability to reflect the risk of T2DM, but AIP may be 
      more closely associated with the risk of T2DM. The current results suggest AIP 
      may be used as a simple, easily calculated parameter in assessing the risk of 
      T2DM.
CI  - Copyright (c) 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Zhu, Xiao-Wei
AU  - Zhu XW
AD  - Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow 
      University, Suzhou, Jiangsu 215123, PR China; Department of Epidemiology, School 
      of Public Health, Soochow University, Suzhou, Jiangsu 215123, PR China.
FAU - Deng, Fei-Yan
AU  - Deng FY
AD  - Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow 
      University, Suzhou, Jiangsu 215123, PR China; Department of Epidemiology, School 
      of Public Health, Soochow University, Suzhou, Jiangsu 215123, PR China.
FAU - Lei, Shu-Feng
AU  - Lei SF
AD  - Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow 
      University, Suzhou, Jiangsu 215123, PR China; Department of Epidemiology, School 
      of Public Health, Soochow University, Suzhou, Jiangsu 215123, PR China. 
      Electronic address: leishufeng@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140505
PL  - England
TA  - Prim Care Diabetes
JT  - Primary care diabetes
JID - 101463825
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
SB  - IM
MH  - Atherosclerosis/*blood/diagnosis/epidemiology
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology
MH  - Dyslipidemias/*blood/diagnosis/epidemiology
MH  - Humans
MH  - Lipids/*blood
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Atherogenic Index of Plasma
OT  - Lipid parameter
OT  - Meta-analysis
OT  - Type 2 diabetes mellitus
EDAT- 2014/05/09 06:00
MHDA- 2015/09/10 06:00
CRDT- 2014/05/10 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/03/05 00:00 [revised]
PHST- 2014/03/26 00:00 [accepted]
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
AID - S1751-9918(14)00044-8 [pii]
AID - 10.1016/j.pcd.2014.03.007 [doi]
PST - ppublish
SO  - Prim Care Diabetes. 2015 Feb;9(1):60-7. doi: 10.1016/j.pcd.2014.03.007. Epub 2014 
      May 5.