PMID- 24810208
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20140708
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 23
IP  - 7
DP  - 2014 Aug
TI  - Nonconvulsive status epilepticus in patients with brain tumors.
PG  - 542-7
LID - S1059-1311(14)00104-6 [pii]
LID - 10.1016/j.seizure.2014.04.003 [doi]
AB  - PURPOSE: The prevalence of nonconvulsive status epilepticus (NCSE) in brain tumor 
      patients is unknown. Since NCSE has been associated with significant mortality 
      and morbidity, early identification is essential. This study describes the 
      clinical and EEG characteristics, treatment, and outcome in brain tumor patients 
      with NCSE. METHOD: All patients admitted to Mount Sinai Hospital from 2009 to 
      2012 with an ICD-9 brain tumor code were cross-referenced with the epilepsy 
      department's database. EEGs from matching patients were reviewed for NCSE. 
      Relevant information from the medical records of the patients with NCSE was 
      extracted. RESULTS: 1101 brain tumor patients were identified, of which 259 (24%) 
      had an EEG and 24 (2%) had NCSE. The vast majority of seizures captured were 
      subclinical with 13 patients (54%) having only subclinical seizures. Treatment 
      resolved the NCSE in 22 patients (92%) with accompanying clinical improvement in 
      18 (75%) of those patients. Tumor recurrence or progression on MRI was associated 
      with decreased 2-month survival (75% mortality, p=0.035) compared to stable 
      tumors (20% mortality). Patients with metastatic disease had median survival from 
      tumor diagnosis of 1.2 months. CONCLUSION: NCSE in brain tumor patients may be 
      under diagnosed due to the frequent lack of outward manifestations and highly 
      treatable with improvement in the majority of patients. NCSE patients with 
      progressing brain lesions, tumor recurrence, or metastatic disease are at serious 
      risk of mortality within 2 months. Continuous EEG monitoring in brain tumor 
      patients with recent clinical seizures and/or a depressed level of consciousness 
      may be critical in providing appropriate care.
CI  - Copyright (c) 2014 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Marcuse, Lara V
AU  - Marcuse LV
AD  - Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New 
      York, NY 10029, USA. Electronic address: lara.marcuse@mssm.edu.
FAU - Lancman, Guido
AU  - Lancman G
AD  - Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New 
      York, NY 10029, USA.
FAU - Demopoulos, Alexis
AU  - Demopoulos A
AD  - North Shore University Hospital, North Shore University Hospital, 200 Community 
      Drive, Manahasset, NY 11030, USA.
FAU - Fields, Madeline
AU  - Fields M
AD  - Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New 
      York, NY 10029, USA.
LA  - eng
PT  - Journal Article
DEP - 20140413
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Neoplasms/*epidemiology
MH  - Databases, Factual
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Status Epilepticus/*epidemiology
OTO - NOTNLM
OT  - Brain tumors
OT  - Critical care
OT  - EEG
OT  - Epilepsy monitoring
OT  - Status epilepticus
EDAT- 2014/05/09 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/05/10 06:00
PHST- 2014/02/24 00:00 [received]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - S1059-1311(14)00104-6 [pii]
AID - 10.1016/j.seizure.2014.04.003 [doi]
PST - ppublish
SO  - Seizure. 2014 Aug;23(7):542-7. doi: 10.1016/j.seizure.2014.04.003. Epub 2014 Apr 
      13.