PMID- 24810360
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20161230
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 44
IP  - 1
DP  - 2016
TI  - Synthesis of calcium phosphate-zirconia scaffold and human endometrial adult stem 
      cells for bone tissue engineering.
PG  - 66-73
LID - 10.3109/21691401.2014.909825 [doi]
AB  - To address the hypothesis that using a zirconia (ZrO2)/ beta-tricalcium phosphate 
      (beta-TCP) composite might improve both the mechanical properties and cellular 
      compatibility of the porous material, we fabricated ZrO2/beta-TCP composite 
      scaffolds with different ZrO2/beta-TCP ratios, and evaluated their physical and 
      mechanical characteristics, also the effect of three-dimensional (3D) culture 
      (ZrO2/beta-TCP scaffold) on the behavior of human endometrial stem cells. Results 
      showed the porosity of a ZrO2/beta-TCP scaffold can be adjusted from 65% to 84%, and 
      the compressive strength of the scaffold increased from 4.95 to 6.25 MPa when the 
      ZrO2 content increased from 30 to 50 wt%. The cell adhesion and proliferation in 
      the ZrO2/beta-TCP scaffold was greatly improved when ZrO2 decreased. Moreover, in 
      vitro study showed that an osteoblasts-loaded ZrO2/beta-TCP scaffold provided a 
      suitable 3D environment for osteoblast survival and enhanced bone regeneration. 
      We thus showed that a porous ZrO2/beta-TCP composite scaffold has excellent 
      mechanical properties, and cellular/tissue compatibility, and would be a 
      promising substrate to achieve both bone reconstruction and regeneration needed 
      during in vivo study for treatment of large bone defects.
FAU - Alizadeh, Aliakbar
AU  - Alizadeh A
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
AD  - c Transplant Research Center, Shiraz University of Medical Sciences , Shiraz , 
      Iran.
FAU - Moztarzadeh, Fathollah
AU  - Moztarzadeh F
AD  - b Department of Biomedical Engineering , Amirkabir University of Technology , 
      Tehran , Iran.
FAU - Ostad, Seyed Naser
AU  - Ostad SN
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
FAU - Azami, Mahmoud
AU  - Azami M
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
FAU - Geramizadeh, Bita
AU  - Geramizadeh B
AD  - c Transplant Research Center, Shiraz University of Medical Sciences , Shiraz , 
      Iran.
FAU - Hatam, Gholamreza
AU  - Hatam G
AD  - d Department of Parasitology , Shiraz University of Medical Sciences , Shiraz , 
      Iran.
FAU - Bizari, Davood
AU  - Bizari D
AD  - b Department of Biomedical Engineering , Amirkabir University of Technology , 
      Tehran , Iran.
FAU - Tavangar, Seyed Mohammad
AU  - Tavangar SM
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
FAU - Vasei, Mohammad
AU  - Vasei M
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
FAU - Ai, Jafar
AU  - Ai J
AD  - a Department of Tissue Engineering , School of Advanced Technologies in Medicine, 
      Tehran University of Medical Sciences , Tehran , Iran.
AD  - e Brain and Spinal Injury Research Center, Imam Hospital, Tehran University of 
      Medical Sciences , Tehran , Iran.
LA  - eng
PT  - Journal Article
DEP - 20140508
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 0 (Biocompatible Materials)
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
RN  - C6V6S92N3C (Zirconium)
RN  - S38N85C5G0 (zirconium oxide)
SB  - IM
MH  - Adult Stem Cells/cytology/*drug effects/metabolism
MH  - Biocompatible Materials
MH  - Bone Regeneration
MH  - Bone and Bones/cytology/drug effects/metabolism
MH  - Calcium Phosphates/chemistry/*pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Endometrium/cytology/drug effects/metabolism
MH  - Female
MH  - Humans
MH  - Osteoblasts/cytology/drug effects/metabolism
MH  - Osteogenesis/drug effects
MH  - Porosity
MH  - Tissue Culture Techniques
MH  - *Tissue Engineering
MH  - *Tissue Scaffolds
MH  - Zirconium/chemistry/*pharmacology
OTO - NOTNLM
OT  - bone tissue engineering
OT  - endometrial stem cells
OT  - porous scaffold
OT  - zirconia
OT  - beta-tricalcium phosphate
EDAT- 2014/05/09 06:00
MHDA- 2016/10/12 06:00
CRDT- 2014/05/10 06:00
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - 10.3109/21691401.2014.909825 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2016;44(1):66-73. doi: 
      10.3109/21691401.2014.909825. Epub 2014 May 8.