PMID- 24810885
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220310
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 571
DP  - 2014 Jun 13
TI  - Increased serum brain-derived neurotrophic factor levels during opiate 
      withdrawal.
PG  - 61-5
LID - S0304-3940(14)00359-0 [pii]
LID - 10.1016/j.neulet.2014.04.048 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in the 
      pathophysiology of opiate addiction. Both increased and decreased serum BDNF 
      levels have been reported in heroin addicts. Moreover, the role of BDNF in 
      heroin-dependent patients during withdrawal has not been studied. This study 
      aimed to explore the differences in serum BDNF levels of heroin addicts and 
      healthy controls, and investigate the changes of serum BDNF levels in heroin 
      addicts at baseline and at one month after heroin cessation. Seventy-two 
      heroin-dependent patients and ninety age- and gender-matched healthy controls 
      were enrolled in this study. We measured serum BDNF levels at baseline (both 
      heroin addicts and healthy controls) and one month after heroin cessation (heroin 
      addicts only). A total of 37 (51.4%) heroin addicts completed the one-month 
      study. We found that baseline serum BDNF levels were significantly higher in 
      heroin addicts compared to controls (F=36.5, p=0.001). There was no difference in 
      serum BDNF levels among heroin addicts at baseline and one month after heroin 
      cessation (F=1.101, p=0.301). These results indicate that BDNF may play a 
      critical role in the course of opiate addiction and withdrawal.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Jie
AU  - Zhang J
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Zhang, XiangYang
AU  - Zhang X
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China; Department of 
      Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The 
      University of Texas Health Science Center at Houston, Houston, TX, USA. 
      Electronic address: zhangxy9@gmail.com.
FAU - Su, Hang
AU  - Su H
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Tao, JingYan
AU  - Tao J
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Xie, Ying
AU  - Xie Y
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Han, Bin
AU  - Han B
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Lu, YuLing
AU  - Lu Y
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Wei, YouDan
AU  - Wei Y
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Sun, HaiWei
AU  - Sun H
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Wang, Yue
AU  - Wang Y
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Wu, WenXiu
AU  - Wu W
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Zou, ShengZhen
AU  - Zou S
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - Liang, Haiyan
AU  - Liang H
AD  - Department of Neurology, Taizhou Municipal Hospital, Zhejiang, PR China.
FAU - Zoghbi, Anthony William
AU  - Zoghbi AW
AD  - Department of Psychiatry, Columbia University, New York, NY, USA.
FAU - Tang, WenJie
AU  - Tang W
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China.
FAU - He, JinCai
AU  - He J
AD  - The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      PR China. Electronic address: hjc@wzmc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140505
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 70D95007SX (Heroin)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Heroin/*adverse effects
MH  - Heroin Dependence/*blood
MH  - Humans
MH  - Male
MH  - Substance Withdrawal Syndrome/blood
OTO - NOTNLM
OT  - Addiction
OT  - Brain-derived neurotrophic factor
OT  - Opiate
OT  - Withdrawal
EDAT- 2014/05/09 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/05/10 06:00
PHST- 2014/03/15 00:00 [received]
PHST- 2014/04/28 00:00 [revised]
PHST- 2014/04/29 00:00 [accepted]
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0304-3940(14)00359-0 [pii]
AID - 10.1016/j.neulet.2014.04.048 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Jun 13;571:61-5. doi: 10.1016/j.neulet.2014.04.048. Epub 2014 
      May 5.