PMID- 24813355
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20151119
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 103
IP  - 8
DP  - 2014 Aug
TI  - Increased circulating inflammatory markers may indicate that formula-fed children 
      are at risk of atherosclerosis.
PG  - e354-8
LID - 10.1111/apa.12680 [doi]
AB  - AIM: The aim of this study was to determine whether formula-fed children have 
      higher serum monocyte chemoattractant protein-1 (MCP-1) and uric acid levels than 
      breast-fed children and to evaluate the association between these inflammatory 
      markers and breastfeeding duration. METHODS: The study group consisted of 87 
      patients aged between five and 32 months. Participants were divided into 
      breast-fed and formula-fed groups and into age groups of </=12 months and 
      >12 months. MCP-1 was measured by the commercial immunoenzymatic ELISA kit, and 
      uric acid was assessed using the colorimetric method. RESULTS: Children in the 
      formula-fed group had statistically significant higher serum MCP-1 and uric acid 
      levels than breast-fed children (p < 0.01 and p < 0.05, respectively). 
      Anthropometric parameters were comparable in both groups. Serum MCP-1 and uric 
      acid levels were negatively correlated with duration of breastfeeding (p < 0.01 
      and p < 0.05). There was a positive relationship between serum MCP-1 and uric 
      acid concentrations (r = 0.27, p < 0.05). CONCLUSION: Increased circulating 
      inflammatory markers may indicate that formula-fed children are at risk of 
      atherosclerosis. However, further studies are needed.
CI  - (c)2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Roszkowska, Renata
AU  - Roszkowska R
AD  - Department of Paediatrics and Nephrology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Taranta-Janusz, Katarzyna
AU  - Taranta-Janusz K
FAU - Tenderenda-Banasiuk, Edyta
AU  - Tenderenda-Banasiuk E
FAU - Wasilewska, Anna
AU  - Wasilewska A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140526
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Atherosclerosis/*etiology
MH  - Biomarkers/blood
MH  - *Breast Feeding
MH  - Chemokine CCL2/*blood
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Infant Formula
MH  - Inflammation/blood
MH  - Male
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Breastfeeding
OT  - Monocyte chemoattractant protein-1
OT  - Uric acid
EDAT- 2014/05/13 06:00
MHDA- 2015/04/23 06:00
CRDT- 2014/05/13 06:00
PHST- 2014/03/24 00:00 [received]
PHST- 2014/05/06 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
AID - 10.1111/apa.12680 [doi]
PST - ppublish
SO  - Acta Paediatr. 2014 Aug;103(8):e354-8. doi: 10.1111/apa.12680. Epub 2014 May 26.