PMID- 2481370
OWN - NLM
STAT- MEDLINE
DCOM- 19900201
LR  - 20191029
IS  - 0042-6857 (Print)
IS  - 0042-6857 (Linking)
VI  - 39
IP  - 1
DP  - 1989 Jun
TI  - [Changes in cerebral level of monoamines by Japanese encephalitis virus 
      infection].
PG  - 47-54
AB  - The changes in monoamine levels of different brain regions following Japanese 
      encephalitis virus (JEV) intraperitoneal inoculation were examined in 
      experimentally JEV-infected mice. In addition, virus distribution was studied 
      using infectivity assay and immuno-histochemistry of viral antigen. 1) The level 
      of monoamines in brain tissues was not affected by 48 hours after viral 
      inoculation, but marked effects were elicited at 96 hours after the inoculation. 
      The cerebral concentration of 5-hydroxyindole-3-acetic acid (5 HIAA) was 
      increased, while that of dopamine (DA) showed a decrease. Especially these 
      alteration were observed in the cerebral cortex, but not in the cerebellum. 2) 
      The viral growth in the brain was observed at 48 hours after the inoculation. The 
      growth in the cerebellum, however, was found to be lower than those in other 
      cerebral regions. 3) The viral antigen was detected in the cerebral cortex, 
      hippocampus, mesencephalon and diencephalon in addition to the substantia nigra 
      and striatum. From these results, it is presumed that clinical manifestation of 
      JEV infection may involve the changes in the metabolism of neurotransmitter, 
      especially those of DA and serotonin in the brain.
FAU - Yamashita, Y
AU  - Yamashita Y
FAU - Ito, T
AU  - Ito T
FAU - Hashimoto, I
AU  - Hashimoto I
FAU - Ohyama, A
AU  - Ohyama A
FAU - Kuriyama, K
AU  - Kuriyama K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Uirusu
JT  - Uirusu
JID - 0417475
RN  - 0 (Biogenic Monoamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Biogenic Monoamines/*metabolism
MH  - Brain/*metabolism
MH  - Dopamine/metabolism
MH  - Encephalitis, Japanese/*metabolism
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Mice
MH  - Norepinephrine/metabolism
MH  - Serotonin/metabolism
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.2222/jsv.39.47 [doi]
PST - ppublish
SO  - Uirusu. 1989 Jun;39(1):47-54. doi: 10.2222/jsv.39.47.