PMID- 24815376
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20140613
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 736
DP  - 2014 Aug 5
TI  - Central injection of L- and D-aspartate attenuates isolation-induced stress 
      behavior in chicks possibly through different mechanisms.
PG  - 138-42
LID - S0014-2999(14)00338-0 [pii]
LID - 10.1016/j.ejphar.2014.04.042 [doi]
AB  - Intracerebroventricular (i.c.v.) injection of L- and D-aspartate (L- and D-Asp) 
      has been shown to have a sedative effect with and without a hypnotic effect, 
      respectively, in neonatal chicks experiencing isolation stress. However, the 
      mechanisms of the different stress-attenuating functions of L- and D-Asp have not 
      yet been fully clarified. In the present study, we investigated the involvement 
      of the N-methyl-D-aspartate (NMDA) receptor in order to reveal the 
      receptor-mediated function of L- and D-Asp. To reveal whether L-and D-Asp act 
      through the NMDA receptor, (+)-MK-801, which is an antagonist of NMDA receptors, 
      was used in the current study. In experiment 1, the chicks were injected i.c.v. 
      with either saline, (+)-MK-801, L-Asp or L-Asp plus (+)-MK-801. The sedative and 
      hypnotic effects induced by L-Asp were blocked by co-administration with 
      (+)-MK-801. In experiment 2, the chicks were injected i.c.v. with either saline, 
      (+)-MK-801, D-Asp or D-Asp plus (+)-MK-801. Importantly, the sedative effects 
      induced by D-Asp were shifted to hypnotic effects by co-administration with 
      (+)-MK-801. Taken together, L-Asp could induce sedative and hypnotic effects for 
      stress behaviors through the NMDA receptor, but the attenuation of stress 
      behaviors by D-Asp might be via simultaneous involvement of other receptors 
      besides the NMDA receptor in this process. These differences may explain the 
      different functional mechanisms of L- and D-Asp in the central nervous system.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Erwan, Edi
AU  - Erwan E
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Chowdhury, Vishwajit Sur
AU  - Chowdhury VS
AD  - Division for Arts and Science, Faculty of Arts and Science, Kyushu University, 
      Fukuoka 819-0395, Japan.
FAU - Nagasawa, Mao
AU  - Nagasawa M
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Goda, Ryosei
AU  - Goda R
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Otsuka, Tsuyoshi
AU  - Otsuka T
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Yasuo, Shinobu
AU  - Yasuo S
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Furuse, Mitsuhiro
AU  - Furuse M
AD  - Laboratory of Regulation in Metabolism and Behavior, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan. Electronic address: furuse@brs.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140509
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Aspartic Acid/*administration & dosage
MH  - Behavior, Animal/*drug effects
MH  - Chickens
MH  - Dizocilpine Maleate/pharmacology
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Injections, Intraventricular
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Social Isolation
MH  - Stress, Psychological/*drug therapy/metabolism
OTO - NOTNLM
OT  - Chick
OT  - D-Aspartate
OT  - Intracerebroventricular
OT  - L-Aspartate
OT  - NMDA receptor
EDAT- 2014/05/13 06:00
MHDA- 2015/02/14 06:00
CRDT- 2014/05/13 06:00
PHST- 2014/03/05 00:00 [received]
PHST- 2014/04/02 00:00 [revised]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - S0014-2999(14)00338-0 [pii]
AID - 10.1016/j.ejphar.2014.04.042 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2014 Aug 5;736:138-42. doi: 10.1016/j.ejphar.2014.04.042. Epub 
      2014 May 9.