PMID- 24815964
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20220316
IS  - 1878-1608 (Electronic)
IS  - 1753-3740 (Linking)
VI  - 28
IP  - 1
DP  - 2014 Mar
TI  - Liposomal bupivacaine and clinical outcomes.
PG  - 15-27
LID - S1521-6896(14)00007-X [pii]
LID - 10.1016/j.bpa.2014.02.001 [doi]
AB  - In the multimodal approach to the management of postoperative pain, local 
      infiltration and regional blocks have been increasingly utilized for pain 
      control. One of the limitations of local anesthetics in the postoperative setting 
      is its relatively short duration of action. Multivesicular liposomes containing 
      bupivacaine have been increasingly utilized for their increased duration of 
      action. Compared with bupivacaine HCl, local infiltration of liposomal 
      bupivacaine has shown to have an increase in duration of action and causes delay 
      in peak plasma concentration. In this article, we attempt to review the clinical 
      literature surrounding liposomal bupivacaine and its evolving role in 
      perioperative analgesia. This new bupivacaine formation may have promising 
      implications in postoperative pain control, resulting in increased patient 
      satisfaction and a decrease in both hospital stay and opioid-induced adverse 
      events (AEs). Although more studies are needed, the preliminary clinical trials 
      suggest that liposomal bupivacaine has predictable pharmacokinetics, a similar 
      side effect profile compared with bupivacaine HCl, and is effective in providing 
      increased postoperative pain control.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Tong, Yi Cai Isaac
AU  - Tong YC
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: 
      yctong@partners.org.
FAU - Kaye, Alan David
AU  - Kaye AD
AD  - Department of Anesthesiology, LSU School of Medicine, New Orleans, LA, USA; 
      Department of Pharmacology, LSU School of Medicine, New Orleans, LA, USA. 
      Electronic address: alankaye44@hotmail.com.
FAU - Urman, Richard D
AU  - Urman RD
AD  - Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. Electronic 
      address: rurman@partners.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20140315
PL  - Netherlands
TA  - Best Pract Res Clin Anaesthesiol
JT  - Best practice & research. Clinical anaesthesiology
JID - 101121446
RN  - 0 (Anesthetics, Local)
RN  - 0 (Liposomes)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Anesthetics, Local/*administration & dosage/adverse effects/pharmacokinetics
MH  - Bupivacaine/*administration & dosage/adverse effects/pharmacokinetics
MH  - Drug Design
MH  - Humans
MH  - Length of Stay
MH  - Liposomes
MH  - Nerve Block/methods
MH  - Pain, Postoperative/*drug therapy
MH  - Patient Satisfaction
MH  - Perioperative Care/methods
OTO - NOTNLM
OT  - adult anesthetics
OT  - local/administration and dosage anesthetics
OT  - local/adverse effects anesthetics
OT  - local/therapeutic use bupivacaine/administration and dosage bupivacaine/adverse 
      effects bupivacaine/therapeutic use
EDAT- 2014/05/13 06:00
MHDA- 2015/01/03 06:00
CRDT- 2014/05/13 06:00
PHST- 2013/09/27 00:00 [received]
PHST- 2014/02/09 00:00 [revised]
PHST- 2014/02/19 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
AID - S1521-6896(14)00007-X [pii]
AID - 10.1016/j.bpa.2014.02.001 [doi]
PST - ppublish
SO  - Best Pract Res Clin Anaesthesiol. 2014 Mar;28(1):15-27. doi: 
      10.1016/j.bpa.2014.02.001. Epub 2014 Mar 15.