PMID- 24816460
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20141201
IS  - 1876-4347 (Electronic)
IS  - 1871-6784 (Linking)
VI  - 32
IP  - 1
DP  - 2015 Jan 25
TI  - Synthetic mRNAs for manipulating cellular phenotypes: an overview.
PG  - 229-35
LID - S1871-6784(14)00050-8 [pii]
LID - 10.1016/j.nbt.2014.04.008 [doi]
AB  - Availability of high quality synthetic mRNAs (syn-mRNAs) has enabled progress in 
      their applications. Important structural features and quality requirements are 
      discussed. Developments in the application of mRNA-mediated manipulation of cells 
      are presented (i) mRNA-directed expression of antigens in dendritic cells for 
      vaccination projects in oncogenesis, infectious disease and allergy prevention; 
      (ii) reprogramming of human fibroblasts to induced pluripotent stem cells with 
      their subsequent differentiation to the desired cell type; (iii) applications in 
      gene therapy.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Quabius, Elgar Susanne
AU  - Quabius ES
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, 
      Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3, Building 27, D-24105 
      Kiel, Germany; Institute of Immunology, Christian-Albrechts-University Kiel, 
      Arnold-Heller-Str. 3, Building 17, D-24105 Kiel, Germany.
FAU - Krupp, Guido
AU  - Krupp G
AD  - AmpTec GmbH, Konigstr. 4A, 22767 Hamburg, Germany. Electronic address: 
      krupp@amp-tec.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140509
PL  - Netherlands
TA  - N Biotechnol
JT  - New biotechnology
JID - 101465345
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Cells/*metabolism
MH  - Genetic Therapy
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunity, Innate
MH  - Phenotype
MH  - RNA, Messenger/chemistry/*metabolism
EDAT- 2014/05/13 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/05/13 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2014/04/22 00:00 [revised]
PHST- 2014/04/23 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S1871-6784(14)00050-8 [pii]
AID - 10.1016/j.nbt.2014.04.008 [doi]
PST - ppublish
SO  - N Biotechnol. 2015 Jan 25;32(1):229-35. doi: 10.1016/j.nbt.2014.04.008. Epub 2014 
      May 9.