PMID- 24817844
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 8
DP  - 2014
TI  - Mice with altered BDNF signaling as models for mood disorders and antidepressant 
      effects.
PG  - 143
LID - 10.3389/fnbeh.2014.00143 [doi]
LID - 143
AB  - Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB 
      support neuronal survival during development and promote connectivity and 
      plasticity in the adult brain. Decreased BDNF signaling is associated with the 
      pathophysiology of depression and the mechanisms underlying the actions of 
      antidepressant drugs (AD). Several transgenic mouse models with decreases or 
      increases in the amount of BDNF or the activity of TrkB signaling have been 
      created. This review summarizes the studies where various mouse models with 
      increased or decreased BDNF levels or TrkB signaling were used to evaluate the 
      role of BDNF signaling in depression-like behavior. Although a large number of 
      models have been employed and several studies have been published, no clear-cut 
      connections between BDNF levels or signaling and depression-like behavior in mice 
      have emerged. However, it is clear that BDNF plays a critical role in the 
      mechanisms underlying the actions of AD.
FAU - Lindholm, Jesse S O
AU  - Lindholm JS
AD  - Neuroscience Center, University of Helsinki Helsinki, Finland.
FAU - Castren, Eero
AU  - Castren E
AD  - Neuroscience Center, University of Helsinki Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140430
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4012208
OTO - NOTNLM
OT  - BDNF
OT  - Bdnf deficient mice
OT  - TrkB signaling
OT  - behavior
OT  - depression
OT  - neurotrophins
OT  - transgenic
EDAT- 2014/05/13 06:00
MHDA- 2014/05/13 06:01
PMCR- 2014/01/01
CRDT- 2014/05/13 06:00
PHST- 2014/02/26 00:00 [received]
PHST- 2014/04/10 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2014/05/13 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2014.00143 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Apr 30;8:143. doi: 10.3389/fnbeh.2014.00143. 
      eCollection 2014.