PMID- 24818041
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2090-908X (Print)
IS  - 2090-908X (Electronic)
IS  - 2090-908X (Linking)
VI  - 2014
DP  - 2014
TI  - Distinct functions of specialized dendritic cell subsets in atherosclerosis and 
      the road ahead.
PG  - 952625
LID - 10.1155/2014/952625 [doi]
LID - 952625
AB  - Atherosclerotic vascular disease is modulated by immune mechanisms. Dendritic 
      cells (DCs) and T cells are present within atherosclerotic lesions and function 
      as central players in the initiation and modulation of adaptive immune responses. 
      In previous years, we have studied the functional contribution of distinct DC 
      subsets in disease development, namely, that of CCL17-expressing DCs as well as 
      that of plasmacytoid DCs that play specialized roles in disease development. This 
      review focuses on important findings gathered in these studies and dissects the 
      multifaceted contribution of CCL17-expressing DCs and pDCs to the pathogenesis of 
      atherosclerosis. Furthermore, an outlook on future challenges faced when studying 
      DCs in this detrimental disease are provided, and hurdles that will need to be 
      overcome in order to enable a better understanding of the contribution of DCs to 
      atherogenesis are discussed, a prerequisite for their therapeutic targeting in 
      atherosclerosis.
FAU - Zernecke, Alma
AU  - Zernecke A
AUID- ORCID: 0000-0001-8551-4729
AD  - Institute of Clinical Biochemistry and Pathobiochemistry, University Hospital 
      Wurzburg, Josef-Schneider-Strasse 2, 97080 Wurzburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140410
PL  - Egypt
TA  - Scientifica (Cairo)
JT  - Scientifica
JID - 101589932
PMC - PMC4003768
EDAT- 2014/05/13 06:00
MHDA- 2014/05/13 06:01
PMCR- 2014/01/01
CRDT- 2014/05/13 06:00
PHST- 2014/01/02 00:00 [received]
PHST- 2014/03/20 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2014/05/13 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.1155/2014/952625 [doi]
PST - ppublish
SO  - Scientifica (Cairo). 2014;2014:952625. doi: 10.1155/2014/952625. Epub 2014 Apr 
      10.