PMID- 24818146
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Potential therapeutic effects of neurotrophins for acute and chronic neurological 
      diseases.
PG  - 601084
LID - 10.1155/2014/601084 [doi]
LID - 601084
AB  - The neurotrophins (NTs) nerve growth factor (NGF), brain-derived neurotrophic 
      factor (BDNF), NT-3, and NT-4/5 are proteins that regulate cell proliferation, 
      differentiation, and survival in both the developing and mature central nervous 
      system (CNS) by binding to two receptor classes, Trk receptors and p75 NTR. 
      Motivated by the broad growth- and survival-promoting effects of these proteins, 
      numerous studies have attempted to use exogenous NTs to prevent the death of 
      cells that are associated with neurological disease or promote the regeneration 
      of severed axons caused by mechanical injury. Indeed, such neurotrophic effects 
      have been repeatedly demonstrated in animal models of stroke, nerve injury, and 
      neurodegenerative disease. However, limitations, including the short biological 
      half-lives and poor blood-brain permeability of these proteins, prevent routine 
      application from treating human disease. In this report, we reviewed evidence for 
      the neuroprotective efficacy of NTs in animal models, highlighting outstanding 
      technical challenges and discussing more recent attempts to harness the 
      neuroprotective capacity of endogenous NTs using small molecule inducers and cell 
      transplantation.
FAU - Cai, Junying
AU  - Cai J
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Hua, Fuzhou
AU  - Hua F
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Yuan, Linhui
AU  - Yuan L
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Tang, Wei
AU  - Tang W
AD  - Department of Urology, The Second Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China.
FAU - Lu, Jun
AU  - Lu J
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Yu, Shuchun
AU  - Yu S
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Wang, Xifeng
AU  - Wang X
AD  - Department of Anesthesiology, The first Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Hu, Yanhui
AU  - Hu Y
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140409
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Chronic Disease
MH  - Humans
MH  - Nerve Growth Factors/*therapeutic use
MH  - Nervous System Diseases/*drug therapy
MH  - Neurodegenerative Diseases/drug therapy
MH  - Neuroprotective Agents/pharmacology/therapeutic use
PMC - PMC4000962
EDAT- 2014/05/13 06:00
MHDA- 2014/12/30 06:00
PMCR- 2014/04/09
CRDT- 2014/05/13 06:00
PHST- 2014/02/25 00:00 [received]
PHST- 2014/03/25 00:00 [accepted]
PHST- 2014/05/13 06:00 [entrez]
PHST- 2014/05/13 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2014/04/09 00:00 [pmc-release]
AID - 10.1155/2014/601084 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:601084. doi: 10.1155/2014/601084. Epub 2014 Apr 9.