PMID- 24818561
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20211021
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 66
IP  - 7-8
DP  - 2014 Aug
TI  - Association of killer cell immunoglobulin-like receptor gene 2DL1 and its HLA-C2 
      ligand with family history of cancer in oral squamous cell carcinoma.
PG  - 439-48
LID - 10.1007/s00251-014-0778-1 [doi]
AB  - Killer cell immunoglobulin-like receptors (KIR) are involved in regulating 
      natural killer cell activation through recognition of their human leukocyte 
      antigen (HLA) class I ligands. We conducted a case-control study with 169 oral 
      squamous cell carcinoma (OSCC) patients and 177 healthy participants to study the 
      genomic diversity of KIR and HLA loci and KIR gene expression in context of 
      family history of cancer (FHC) in OSCC. Polymerase chain reaction (PCR) 
      sequence-specific priming approach was used to type 16 KIR genes in individuals. 
      SSP-real-time PCR was used for HLA class I ligand genotyping and real-time 
      quantitative reverse transcriptase PCR was used to determine the expression of 
      KIR gene. KIR2DL1(+)-HLA-C2(+) genotype was higher and positively associated with 
      OSCC. Notably, all KIR2DL1(+)-HLA-C2(+) genotypes occurred exclusively in 
      patients with FHC, showing a strong positive association of KIR2DL1(+)-HLA-C2(+) 
      genotype with FHC. In addition, all younger age group patients (<55 years) with 
      FHC were positive for KIR2DL1(+)-HLA-C2(+) genotype suggesting association of the 
      genotype with early onset of disease. RNA transcript abundance of inhibitory 
      KIR2DL1 in FHC patients, particularly of lower age groups (<45 and 45-54 years), 
      supports the contention. Further, KIR2DL3(+)-HLA-C(+) genotype was negatively 
      associated with OSCC. Our findings suggest KIR2DL1(+)-HLA-C2(+) genotype as 
      heritable risk factor in OSCC predisposing to OSCC at younger age. Interestingly, 
      KIR2DL3(+)-HLA-C(+) genotype was seen to be protective in OSCC. This study may be 
      useful towards cancer surveillance and early detection of oral cancer in patients 
      with FHC.
FAU - Dutta, Anupam
AU  - Dutta A
AD  - Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, 
      Tezpur, 784028, Assam, India.
FAU - Saikia, Nabajyoti
AU  - Saikia N
FAU - Phookan, Jyotirmoy
AU  - Phookan J
FAU - Baruah, Munindra Narayan
AU  - Baruah MN
FAU - Baruah, Shashi
AU  - Baruah S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140513
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL1 protein, human)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (Ligands)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Receptors, KIR2DL1)
RN  - 0 (Receptors, KIR2DL3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/*immunology/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - Genetic Predisposition to Disease
MH  - HLA-C Antigens/genetics/*metabolism
MH  - Humans
MH  - Ligands
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/*immunology/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - RNA, Neoplasm/genetics/metabolism
MH  - Receptors, KIR2DL1/*genetics
MH  - Receptors, KIR2DL3/genetics
EDAT- 2014/05/14 06:00
MHDA- 2014/10/07 06:00
CRDT- 2014/05/14 06:00
PHST- 2014/01/21 00:00 [received]
PHST- 2014/04/29 00:00 [accepted]
PHST- 2014/05/14 06:00 [entrez]
PHST- 2014/05/14 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1007/s00251-014-0778-1 [doi]
PST - ppublish
SO  - Immunogenetics. 2014 Aug;66(7-8):439-48. doi: 10.1007/s00251-014-0778-1. Epub 
      2014 May 13.