PMID- 24818748
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20220410
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 39
IP  - 6
DP  - 2014 Jun
TI  - Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced 
      senescence.
PG  - 268-76
LID - S0968-0004(14)00065-6 [pii]
LID - 10.1016/j.tibs.2014.04.004 [doi]
AB  - Oncogene-induced senescence (OIS) is a tumor-suppressing response that must be 
      disrupted for cancer to develop. Mechanistic insights into OIS have begun to 
      emerge. Activation of the p53/p21(WAF1) and/or p16(INK4A) tumor-suppressor 
      pathways is essential for OIS. Moreover, the DNA damage response, chromatin 
      remodeling, and senescence-associated secretory phenotype (SASP) are important 
      for the initiation and maintenance of OIS. This review discusses recent advances 
      in elucidating the mechanisms of OIS, focusing on the roles of the p38 
      mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase 
      (PI3K)/cellular homolog of murine thymoma virus AKT/mammalian target of rapamycin 
      (mTOR) pathways. These studies indicate that OIS is mediated by an intricate 
      signaling network. Further delineation of this network may lead to development of 
      new cancer therapies targeting OIS.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Xu, Yingxi
AU  - Xu Y
AD  - College of Medicine, Nankai University, 94 Weijin Road, Tianjin, China, 300071; 
      Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 
      North Torrey Pines Road, La Jolla, CA 92037, USA.
FAU - Li, Na
AU  - Li N
AD  - College of Medicine, Nankai University, 94 Weijin Road, Tianjin, China, 300071.
FAU - Xiang, Rong
AU  - Xiang R
AD  - College of Medicine, Nankai University, 94 Weijin Road, Tianjin, China, 300071.
FAU - Sun, Peiqing
AU  - Sun P
AD  - Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 
      North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: 
      pqsun@scripps.edu.
LA  - eng
GR  - R01 CA131231/CA/NCI NIH HHS/United States
GR  - CA172115/CA/NCI NIH HHS/United States
GR  - R01 CA172115/CA/NCI NIH HHS/United States
GR  - CA131231/CA/NCI NIH HHS/United States
GR  - R01 CA106768/CA/NCI NIH HHS/United States
GR  - CA106768/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140509
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cellular Senescence/*genetics
MH  - Humans
MH  - *Oncogenes
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
PMC - PMC4358807
MID - NIHMS668657
OTO - NOTNLM
OT  - AKT
OT  - oncogene-induced senescence
OT  - p38
OT  - phosphoinositide 3-kinase
EDAT- 2014/05/14 06:00
MHDA- 2015/04/07 06:00
PMCR- 2015/06/01
CRDT- 2014/05/14 06:00
PHST- 2014/03/23 00:00 [received]
PHST- 2014/04/08 00:00 [revised]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/05/14 06:00 [entrez]
PHST- 2014/05/14 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - S0968-0004(14)00065-6 [pii]
AID - 10.1016/j.tibs.2014.04.004 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2014 Jun;39(6):268-76. doi: 10.1016/j.tibs.2014.04.004. Epub 
      2014 May 9.