PMID- 24819157 OWN - NLM STAT- MEDLINE DCOM- 20150629 LR - 20211021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 9 IP - 5 DP - 2014 TI - Development of a new risk score for incident type 2 diabetes using updated diagnostic criteria in middle-aged and older chinese. PG - e97042 LID - 10.1371/journal.pone.0097042 [doi] LID - e97042 AB - Type 2 diabetes mellitus (T2DM) reaches an epidemic proportion among adults in China. However, no simple score has been created for the prediction of T2DM incidence diagnosed by updated criteria with hemoglobin A1c (HbA1c) >/= 6.5% included in Chinese. In a 6-year follow-up cohort in Beijing and Shanghai, China, we recruited a total of 2529 adults aged 50-70 years in 2005 and followed them up in 2011. Fasting plasma glucose (FPG), HbA1c, and C-reactive protein (CRP) were measured and incident diabetes was identified by the recently updated criteria. Of the 1912 participants without T2DM at baseline, 924 were identified as having T2DM at follow-up, and most of them (72.4%) were diagnosed using the HbA1c criterion. Baseline body mass index, FPG, HbA1c, CRP, hypertension, and female gender were all significantly associated with incident T2DM. Based upon these risk factors, a simple score was developed with an estimated area under the receiver operating characteristic curve of 0.714 (95% confidence interval: 0.691, 0.737), which performed better than most of existing risk score models developed for eastern Asian populations. This simple, newly constructed score of six parameters may be useful in predicting T2DM in middle-aged and older Chinese. FAU - Ye, Xingwang AU - Ye X AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China; SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. FAU - Zong, Geng AU - Zong G AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Liu, Xin AU - Liu X AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Liu, Gang AU - Liu G AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Gan, Wei AU - Gan W AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Zhu, Jingwen AU - Zhu J AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Lu, Ling AU - Lu L AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Sun, Liang AU - Sun L AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China; SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. FAU - Li, Huaixing AU - Li H AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. FAU - Hu, Frank B AU - Hu FB AD - Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America. FAU - Lin, Xu AU - Lin X AD - Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140512 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Blood Glucose) RN - 9007-41-4 (C-Reactive Protein) SB - IM EIN - PLoS One. 2014;9(12):e115929 MH - Aged MH - Blood Glucose/metabolism MH - C-Reactive Protein/metabolism MH - China/epidemiology MH - Diabetes Mellitus, Type 2/blood/*diagnosis/*epidemiology MH - Fasting/blood MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Models, Statistical MH - Risk Assessment/*methods MH - Risk Factors MH - Sex Distribution PMC - PMC4018395 COIS- Competing Interests: This study was partly supported by Novo Nordisk A/S. Drs. Xingwang Ye and Liang Sun have an affiliation to SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, which is jointly supported by Shanghai Institutes for Biological Sciences and Novo Nordisk. There are no patents, products in development or marketed products to declare. This does not alter adherence to all PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. EDAT- 2014/05/14 06:00 MHDA- 2015/06/30 06:00 PMCR- 2014/05/12 CRDT- 2014/05/14 06:00 PHST- 2014/01/22 00:00 [received] PHST- 2014/04/14 00:00 [accepted] PHST- 2014/05/14 06:00 [entrez] PHST- 2014/05/14 06:00 [pubmed] PHST- 2015/06/30 06:00 [medline] PHST- 2014/05/12 00:00 [pmc-release] AID - PONE-D-14-03413 [pii] AID - 10.1371/journal.pone.0097042 [doi] PST - epublish SO - PLoS One. 2014 May 12;9(5):e97042. doi: 10.1371/journal.pone.0097042. eCollection 2014.