PMID- 24819931
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20231213
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 55
IP  - 2
DP  - 2015 Feb
TI  - Molecular rescue of DYRK1A overexpression in cystathionine beta 
      synthase-deficient mouse brain by enriched environment combined with voluntary 
      exercise.
PG  - 318-23
LID - 10.1007/s12031-014-0324-5 [doi]
AB  - Hyperhomocysteinemia resulting from cystathionine beta synthase (CBS) deficiency 
      can produce cognitive dysfunction. We recently found that CBS-deficient mice 
      exhibit increased expression of the serine/threonine kinase dual-specificity 
      tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A) in the brain. When 
      dysregulated, DYRK1A contributes to the neurodegeneration, neuronal death, and 
      loss of function observed in neurodegenerative diseases. However, brain 
      plasticity can be improved by interventions like enriched environment combined 
      with voluntary exercise (EE/VE). The present study sought to assess the effects 
      of EE/VE on molecular mechanisms linked to DYRK1A overexpression in the brain of 
      CBS-deficient mice. EE/VE was applied to 3-month-old female CBS-deficient mice 
      for 1 month. Without intervention, CBS-deficient mice exhibited increased DYRK1A 
      and decreased brain-derived neurotrophic factor (BDNF) levels in the cortex and 
      hippocampus. However, EE/VE rescued these altered DYRK1A and BDNF levels in the 
      hippocampus of CBS-deficient mice. We conclude that exercise combined with 
      enriched environment can restore the altered molecular mechanisms in the brain of 
      CBS-deficient mice.
FAU - Souchet, Benoit
AU  - Souchet B
AD  - Sorbonne Paris Cite, Unite de Biologie Fonctionnelle et Adaptative (BFA), 
      Universite Paris Diderot, UMR 8251 CNRS, 75205, Paris, France.
FAU - Latour, Alizee
AU  - Latour A
FAU - Gu, Yuchen
AU  - Gu Y
FAU - Daubigney, Fabrice
AU  - Daubigney F
FAU - Paul, Jean-Louis
AU  - Paul JL
FAU - Delabar, Jean-Maurice
AU  - Delabar JM
FAU - Janel, Nathalie
AU  - Janel N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140513
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 4.2.1.22 (Cystathionine beta-Synthase)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cystathionine beta-Synthase/*deficiency/genetics
MH  - Female
MH  - Mice
MH  - *Physical Exertion
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Dyrk Kinases
EDAT- 2014/05/14 06:00
MHDA- 2015/09/12 06:00
CRDT- 2014/05/14 06:00
PHST- 2014/02/08 00:00 [received]
PHST- 2014/05/02 00:00 [accepted]
PHST- 2014/05/14 06:00 [entrez]
PHST- 2014/05/14 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 10.1007/s12031-014-0324-5 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 Feb;55(2):318-23. doi: 10.1007/s12031-014-0324-5. Epub 2014 
      May 13.