PMID- 24821146
OWN - NLM
STAT- MEDLINE
DCOM- 20140708
LR  - 20191112
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 25
IP  - 3
DP  - 2014 May
TI  - Comparison between spousal donor transplantation treated with anti-thymocyte 
      globulin induction therapy and, living related donor transplantation treated with 
      standard immunosuppression.
PG  - 520-3
AB  - The worldwide shortage of organs available for transplantation has led to the use 
      of living-unrelated kidney donors. In this context, spouses represent an 
      important source of organ donors. We compared the allograft outcomes of spousal 
      donor transplantation (SDT) with anti-thymocyte globulin (ATG) induction therapy 
      and living related donor transplantation (LRDT) with triple immonosuppression and 
      basiliximab, in addition. Among the 335 living and deceased donor kidney 
      transplantations performed between April 2001 and June 2010, there were 274 
      living donor kidney transplantations including 34 SDT and 240 LRDT. The minimum 
      follow-up period was 36 months. All recipients of SDT received ATG (1.5 mg/kg) 
      induction therapy, which was stopped five to seven days after surgery. 
      Maintenance immunosuppression included tacrolimus (TAC), mycophenolate mofetil 
      (MMF) and prednisolone. LRDT recipients received triple immunosuppressive 
      protocol consisting of cyclosporine or TAC, MMF and prednisolone, in addition to 
      basiliximab. There was a significant difference between the two groups in 
      recipient age, while pre-operative duration on dialysis, recipient sex and donor 
      age and sex were not significantly different. There was also a significant 
      difference between the two groups in the number of human leukocyte antigen (HLA) 
      mismatches. The 1-, 3- and 5-year graft survival rates of SDT were 94.1%, 88.2% 
      and 79.4%, respectively, and the frequency of acute rejection episodes was 5.8% 
      (two cases). The 1-, 3- and 5-year graft survival rates of LRDT were 95.8%, 91.6% 
      and 83.3%, respectively, with the frequency of acute rejection being 16.2%. The 
      graft survival rates of SDT were as good as LRDT, while the acute rejection rates 
      in SDT were lower than in LRDT, although the difference was not statistically 
      different (P = 0.13).
FAU - Demir, Erkan
AU  - Demir E
FAU - Paydas, Saime
AU  - Paydas S
AD  - Department of Internal Medicine, Division of Nephrology Faculty of Medicine, 
      Cukurova University, Adana, Turkey.
FAU - Erken, Ugur
AU  - Erken U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Antilymphocyte Serum/*therapeutic use
MH  - Drug Therapy, Combination
MH  - *Family
MH  - Female
MH  - Graft Rejection/immunology/mortality/*prevention & control
MH  - Graft Survival/*drug effects
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Kidney Transplantation/adverse effects/*methods/mortality
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - *Spouses
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/05/14 06:00
MHDA- 2014/07/09 06:00
CRDT- 2014/05/14 06:00
PHST- 2014/05/14 06:00 [entrez]
PHST- 2014/05/14 06:00 [pubmed]
PHST- 2014/07/09 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2014_25_3_520_132155 [pii]
AID - 10.4103/1319-2442.132155 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2014 May;25(3):520-3. doi: 10.4103/1319-2442.132155.