PMID- 24821360
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20140806
IS  - 1421-9859 (Electronic)
IS  - 0378-5866 (Linking)
VI  - 36
IP  - 3-4
DP  - 2014
TI  - The role of dopamine D(1) and D(2) receptors in adolescent methylphenidate 
      conditioned place preference: sex differences and brain-derived neurotrophic 
      factor.
PG  - 277-86
LID - 10.1159/000360636 [doi]
AB  - This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate 
      (MPH) conditioned place preference (CPP) in adolescent male and female rats, in 
      addition to the role of these receptors in the effects of MPH on brain-derived 
      neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a 
      nonbiased CPP procedure, the animals were conditioned from postnatal day (PD) 33 
      to 37. On conditioning trials, animals were first administered saline or their 
      respective antagonist (0.1 or 0.2 mg/kg SCH-23390; 0.01 or 0.03 mg/kg eticlopride 
      HCl), followed by MPH (5 mg/kg). Approximately 10 min after MPH administration, 
      the rats were placed into the paired context for a 10-min trial. One day after 
      conditioning on PD38, a preference test was administered with dividers removed. 
      One day following the preference test on PD39, brain tissue was removed, and the 
      nucleus accumbens and striatum were analyzed for BDNF. Results revealed that MPH 
      conditioning resulted in an increased preference that was blocked by either dose 
      of SCH-23390, but generally not affected by either dose of eticlopride. Further, 
      the higher dose of SCH-23390 resulted in a conditioned place aversion in males, 
      presumably due to an increased number of dopamine D1 receptors in adolescent 
      males. MPH produced a significant increase of striatal and accumbal BDNF 
      alleviated by SCH-23390 or eticlopride. These results show that MPH results in 
      CPP in adolescent male and female rats and these effects appear to be mediated by 
      the dopamine D1 receptor, but the effects of MPH on BDNF appear to be mediated by 
      both dopamine receptor families.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Cummins, Elizabeth D
AU  - Cummins ED
AD  - Department of Psychology, East Tennessee State University, Johnson City, Tenn., 
      USA.
FAU - Griffin, Stephen B
AU  - Griffin SB
FAU - Duty, Chase M
AU  - Duty CM
FAU - Peterson, Daniel J
AU  - Peterson DJ
FAU - Burgess, Katherine C
AU  - Burgess KC
FAU - Brown, Russell W
AU  - Brown RW
LA  - eng
PT  - Journal Article
DEP - 20140508
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Conditioning, Operant/*drug effects
MH  - Dopamine Antagonists/pharmacology
MH  - Dopamine Uptake Inhibitors/antagonists & inhibitors/*pharmacology
MH  - Female
MH  - Male
MH  - Methylphenidate/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/*drug effects
MH  - Receptors, Dopamine D2/*drug effects
MH  - Sex Characteristics
EDAT- 2014/05/14 06:00
MHDA- 2015/04/18 06:00
CRDT- 2014/05/14 06:00
PHST- 2013/12/20 00:00 [received]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/05/14 06:00 [entrez]
PHST- 2014/05/14 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
AID - 000360636 [pii]
AID - 10.1159/000360636 [doi]
PST - ppublish
SO  - Dev Neurosci. 2014;36(3-4):277-86. doi: 10.1159/000360636. Epub 2014 May 8.