PMID- 24822313
OWN - NLM
STAT- MEDLINE
DCOM- 20140602
LR  - 20150826
IS  - 0370-629X (Print)
IS  - 0370-629X (Linking)
VI  - 69 Suppl 1
DP  - 2014
TI  - [The therapeutic potential of ablative radiotherapy for metastatic renal cell 
      cancer: a tumour deemed radiation resistant].
PG  - 94-100
AB  - Image guided Stereotactic Body Radiation Therapy (SBRT), is a valuable 
      alternative to other ablative approaches, especially in the context of metastatic 
      renal cell carcinoma (mRCC). The efficacy of this treatment depends on the 
      Biological Effective Dose (BED). The BED is determined by total dose and dose per 
      fraction. The technical possibility of applying high dose per fraction (> 8-10 
      Gy), yielding a distinct biological response which is fundamentally different 
      from the one observed with conventional irradiation, offers high response rates 
      (80-90%) in a tumour which was historically considered "radio resistant". As a 
      part of the increased radiobiological effect can be attributed to vascular 
      catastrophe (endothelial apoptosis triggered by high fractional dose), there is a 
      rationale to investigate association of SBRT and agents targeting tumour 
      angiogenesis in mRCC in upcoming clinical trials.
FAU - Coucke, P
AU  - Coucke P
FAU - Janvary, Z
AU  - Janvary Z
FAU - Jansen, N
AU  - Jansen N
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'interet de la radiotherapie "ablative" en prenant comme modele la metastase 
      d'un cancer renal a cellules claires.
PL  - Belgium
TA  - Rev Med Liege
JT  - Revue medicale de Liege
JID - 0404317
SB  - IM
MH  - Carcinoma, Renal Cell/pathology/*surgery
MH  - Humans
MH  - Kidney Neoplasms/pathology/*surgery
MH  - Neoplasm Metastasis
MH  - Radiation Tolerance
MH  - Radiosurgery/*methods
MH  - Radiotherapy Dosage
MH  - Treatment Outcome
EDAT- 2014/05/16 06:00
MHDA- 2014/06/03 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/06/03 06:00 [medline]
PST - ppublish
SO  - Rev Med Liege. 2014;69 Suppl 1:94-100.