PMID- 24824210
OWN - NLM
STAT- MEDLINE
DCOM- 20150224
LR  - 20221207
IS  - 1531-2267 (Electronic)
IS  - 1094-8341 (Linking)
VI  - 46
IP  - 14
DP  - 2014 Jul 15
TI  - High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless 
      of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.
PG  - 497-504
LID - 10.1152/physiolgenomics.00027.2014 [doi]
AB  - High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 
      diabetes mellitus (T2DM) and improved beta-cell function; genetic factors also 
      determine these risks. This cross-sectional study investigated whether CRF 
      modifies the association of polygenic risk of T2DM with glucose metabolism in 
      nondiabetic Japanese men. Fasting plasma glucose, insulin, and glycated 
      hemoglobin (HbA1c) levels were measured in 174 Japanese men (age: 20-79 yr). 
      beta-Cell function and insulin resistance were evaluated by calculating HOMA-beta and 
      HOMA-IR, respectively. CRF was assessed by measuring maximal oxygen uptake 
      (V̇o2max). Subjects were divided into the low and high CRF groups within each age 
      group according to the median V̇o2max. Eleven single nucleotide polymorphisms 
      (SNPs) associated with T2DM were analyzed and used to calculate genetic risk 
      score (GRS); subjects were divided into the low, middle, and high GRS groups. The 
      high GRS group had higher HbA1c levels than the low GRS group in both the low and 
      high CRF groups (P < 0.05). Furthermore, the individuals with a high GRS had a 
      lower HOMA-beta than those with a low GRS regardless of CRF (P < 0.05). In multiple 
      linear regression analysis, although GRS was a significant predictor of HbA1c (beta 
      = 0.153, P = 0.025), V̇o2max was also associated with HbA1c (beta = -0.240, P = 
      0.041) independent of GRS. These results suggest that CRF is associated with 
      HbA1c levels independent of GRS derived from T2DM-related SNPs; however, it does 
      not modify the association of GRS with increased HbA1c or impaired beta-cell 
      function.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Tanisawa, Kumpei
AU  - Tanisawa K
AD  - Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; 
      Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of 
      Gerontology, Itabashi, Tokyo, Japan;
FAU - Ito, Tomoko
AU  - Ito T
AD  - Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
FAU - Sun, Xiaomin
AU  - Sun X
AD  - Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
FAU - Ise, Ryuken
AU  - Ise R
AD  - Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
FAU - Oshima, Satomi
AU  - Oshima S
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and.
FAU - Cao, Zhen-Bo
AU  - Cao ZB
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and.
FAU - Sakamoto, Shizuo
AU  - Sakamoto S
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and 
      Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, 
      Saitama, Japan.
FAU - Tanaka, Masashi
AU  - Tanaka M
AD  - Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of 
      Gerontology, Itabashi, Tokyo, Japan;
FAU - Higuchi, Mitsuru
AU  - Higuchi M
AD  - Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and 
      Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, 
      Saitama, Japan mhiguchi@waseda.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140513
PL  - United States
TA  - Physiol Genomics
JT  - Physiological genomics
JID - 9815683
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Blood Glucose/genetics/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism
MH  - Glucose/genetics/metabolism
MH  - Glycated Hemoglobin/genetics/*metabolism
MH  - Humans
MH  - Insulin/genetics/metabolism
MH  - Insulin Resistance/genetics
MH  - Insulin-Secreting Cells/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - HbA1c
OT  - cardiorespiratory fitness
OT  - polygenic risk
OT  - beta-cell function
EDAT- 2014/05/16 06:00
MHDA- 2015/02/25 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/02/25 06:00 [medline]
AID - physiolgenomics.00027.2014 [pii]
AID - 10.1152/physiolgenomics.00027.2014 [doi]
PST - ppublish
SO  - Physiol Genomics. 2014 Jul 15;46(14):497-504. doi: 
      10.1152/physiolgenomics.00027.2014. Epub 2014 May 13.