PMID- 24824424
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20180816
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 16
IP  - 4
DP  - 2015 Jun
TI  - Neurobiology and temperament in the offspring of excellent lithium responders.
PG  - 272-7
LID - 10.3109/15622975.2014.913810 [doi]
AB  - OBJECTIVES: The aim of the study was to assess neurobiological and temperamental 
      correlates in offspring of lithium-treated patients, related to parental lithium 
      response. METHODS: The study comprised 27 female and 23 male subjects, aged 17-54 
      years, the offspring of 36 bipolar patients receiving lithium for 5-38 years. 
      Thirteen subjects were offspring of excellent lithium responders (ELR), 25 of 
      partial lithium responders and 12 of lithium non-responders. In all subjects, 
      serum brain-derived neurotrophic factor (BDNF), matrix metalloproteinase-9 
      (MMP-9), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were 
      measured, and the subjects were assessed by the Temperament Scale of Memphis, 
      Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) and the Oxford-Liverpool 
      Inventory of Feelings and Experiences (O-LIFE) scale. RESULTS: In offspring of 
      the ELR, the percentage of persons treated for mood disorder was higher (46 vs. 
      16%), and higher mean BDNF and MMP-9 levels and lower IL-6 levels were found, 
      compared with the remaining subjects. There were also differences between the ELR 
      and the remaining patients on the TEMPS-A and O-LIFE scale, and within the ELR, 
      between subjects treated for mood disorders and the healthy ones. CONCLUSIONS: 
      The offspring of ELR show distinct neurobiological and temperamental profiles 
      compared to other lithium-treated patients.
FAU - Ferensztajn, Ewa
AU  - Ferensztajn E
AD  - Department of Adult Psychiatry, Poznan University of Medical Sciences , Poznan , 
      Poland.
FAU - Skibinska, Maria
AU  - Skibinska M
FAU - Kaczmarek, Mariusz
AU  - Kaczmarek M
FAU - Losy, Jacek
AU  - Losy J
FAU - Rybakowski, Janusz K
AU  - Rybakowski JK
LA  - eng
PT  - Journal Article
DEP - 20140514
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Lithium Compounds)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*therapeutic use
MH  - Biomarkers/*blood
MH  - Bipolar Disorder/*drug therapy
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Lithium Compounds/*therapeutic use
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Mood Disorders/*drug therapy
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
MH  - *Temperament
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
OTO - NOTNLM
OT  - biological markers
OT  - bipolar disorder
OT  - lithium prophylaxis
OT  - offspring
OT  - temperamental assessment
EDAT- 2014/05/16 06:00
MHDA- 2016/02/05 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - 10.3109/15622975.2014.913810 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2015 Jun;16(4):272-7. doi: 10.3109/15622975.2014.913810. 
      Epub 2014 May 14.