PMID- 24824656
OWN - NLM
STAT- MEDLINE
DCOM- 20140827
LR  - 20140702
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Linking)
VI  - 307
IP  - 1
DP  - 2014 Jul 1
TI  - miR-24 regulates menin in the endocrine pancreas.
PG  - E84-92
LID - 10.1152/ajpendo.00542.2013 [doi]
AB  - Menin, the product of the MEN1 gene, functions as a tumor suppressor and was 
      first identified in 1997 due to its causative role in the endocrine tumor 
      disorder multiple endocrine neoplasia, type 1 (MEN1). More recently, menin has 
      been identified as a key player in pancreatic islet biology with the observation 
      of an inverse relationship between menin levels and pancreatic islet 
      proliferation. However, the factors regulating menin and the MEN1 gene in the 
      pancreas are poorly understood. Here, we describe the regulation of menin by 
      miR-24 and demonstrate that miR-24 directly decreases menin levels and impacts 
      downstream cell cycle inhibitors in MIN6 insulinoma cells and in betalox5 
      immortalized beta-cells. This regulation of menin impacts cell viability and 
      proliferation in betalox5 cells. Furthermore, our data show a feedback regulation 
      between miR-24 and menin that is present in the pancreas, suggesting that miR-24 
      regulates menin levels in the pancreatic islet.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Vijayaraghavan, Jyothi
AU  - Vijayaraghavan J
AD  - Department of Genetics, School of Medicine, Louisiana State University Health 
      Sciences Center, New Orleans, Louisiana.
FAU - Maggi, Elaine C
AU  - Maggi EC
AD  - Department of Genetics, School of Medicine, Louisiana State University Health 
      Sciences Center, New Orleans, Louisiana.
FAU - Crabtree, Judy S
AU  - Crabtree JS
AD  - Department of Genetics, School of Medicine, Louisiana State University Health 
      Sciences Center, New Orleans, Louisiana jcrabt@lsuhsc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140513
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Men1 protein, mouse)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn24 microRNA, mouse)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Gene Expression Regulation/*physiology
MH  - Islets of Langerhans/*cytology/*physiopathology
MH  - Mice
MH  - Mice, Knockout
MH  - MicroRNAs/*physiology
MH  - Pancreas/*metabolism
MH  - Proto-Oncogene Proteins/*physiology
OTO - NOTNLM
OT  - MEN1
OT  - menin
OT  - miR-24
OT  - miRNA
OT  - pancreatic islet
EDAT- 2014/05/16 06:00
MHDA- 2014/08/29 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/08/29 06:00 [medline]
AID - ajpendo.00542.2013 [pii]
AID - 10.1152/ajpendo.00542.2013 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E84-92. doi: 
      10.1152/ajpendo.00542.2013. Epub 2014 May 13.