PMID- 24824965
OWN - NLM
STAT- MEDLINE
DCOM- 20141030
LR  - 20220408
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 60
IP  - 3
DP  - 2014 Sep
TI  - Current epidemiology of hepatitis E virus infection in the United States: low 
      seroprevalence in the National Health and Nutrition Evaluation Survey.
PG  - 815-22
LID - 10.1002/hep.27219 [doi]
AB  - Analysis of the National Health and Nutrition Evaluation Survey (NHANES) 
      1988-1994 dataset found a relatively high seroprevalence (21%) of hepatitis E 
      virus (HEV) infection in the U.S. general population. Using data obtained within 
      the NHANES 2009-2010 survey, where a high performance assay for HEV was used, we 
      estimated the weighted seroprevalence of HEV infection among U.S. individuals 6 
      years and older. We also evaluated factors associated with HEV seropositivity. A 
      total of 8,814 individuals were included in the analysis. The median age of study 
      participants was 37 years (interquartile range [IQR] 17-58 years), with 51.2% 
      being female. The weighted national seroprevalence of HEV was 6% (95% confidence 
      interval [CI] 5.1%-6.9%). About 0.5% of those with HEV had evidence of recent 
      exposure (immunoglobulin M-positive). In the univariate analyses, factors 
      associated with HEV seropositivity were increasing age (P-trend<0.001), birth 
      outside of the U.S., Hispanic race, and "meat" consumption (>10 times/month). No 
      significant association was observed with low socioeconomic status, water source, 
      or level of education. In the multivariate analysis, only older age remained 
      predictive of HEV seropositivity. CONCLUSION: The weighted national 
      seroprevalence of HEV in the U.S. is much less than previously reported. Using 
      data obtained with a high performance assay, the seroprevalence of HEV was 
      estimated at 6.0% in the U.S. Based on these results, the seroprevalence of HEV 
      is only one-third as high as previously reported.
CI  - (c) 2014 by the American Association for the Study of Liver Diseases.
FAU - Ditah, Ivo
AU  - Ditah I
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
FAU - Ditah, Fausta
AU  - Ditah F
FAU - Devaki, Pardha
AU  - Devaki P
FAU - Ditah, Calistus
AU  - Ditah C
FAU - Kamath, Patrick S
AU  - Kamath PS
FAU - Charlton, Michael
AU  - Charlton M
LA  - eng
PT  - Journal Article
DEP - 20140717
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
SB  - IM
CIN - Hepatology. 2015 Apr;61(4):1442. PMID: 24995541
CIN - Hepatology. 2015 Apr;61(4):1441-2. PMID: 24995930
CIN - Hepatology. 2015 Apr;61(4):1442-3. PMID: 25598196
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Female
MH  - Hepatitis E/blood/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Pregnancy
MH  - Prevalence
MH  - Risk Factors
MH  - Seroepidemiologic Studies
MH  - United States/epidemiology
MH  - Young Adult
EDAT- 2014/05/16 06:00
MHDA- 2014/10/31 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/05/09 00:00 [accepted]
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/10/31 06:00 [medline]
AID - 10.1002/hep.27219 [doi]
PST - ppublish
SO  - Hepatology. 2014 Sep;60(3):815-22. doi: 10.1002/hep.27219. Epub 2014 Jul 17.