PMID- 24825093
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20151119
IS  - 0334-1763 (Print)
IS  - 0334-1763 (Linking)
VI  - 25
IP  - 4
DP  - 2014
TI  - Protein markers of cerebrovascular disruption of neurovascular unit: 
      immunohistochemical and imaging approaches.
PG  - 481-507
LID - 10.1515/revneuro-2013-0041 [doi]
AB  - Currently, there is great interest in the assembly and function of cerebral 
      endothelial, glial and neuronal cells that form the anatomical basis of the 
      neurovascular unit (NVU) to maintain blood-brain barrier (BBB) and cerebral blood 
      flow. Recent studies have provided considerable insight into the assembly of the 
      components of the NVU. However, there is still paucity of data regarding the 
      identification and expression pattern of these components in various pathologies 
      of the central nervous system. Here, we provide a brief overview of the 
      histological and imaging methods to study BBB disruption in various experimental 
      settings especially the ischemia models associated with necrosis. Emphasis is on 
      the immunohistochemistry of various protein markers of NVU. An understanding of 
      the alterations in the expression pattern of these markers in various 
      neurodegenerative disorders could lead to a better understanding of the 
      conditions that cause BBB disruption as well as to the development of new 
      restorative and protective treatments.
FAU - Amtul, Zareen
AU  - Amtul Z
FAU - Hepburn, Jeffrey D
AU  - Hepburn JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Aquaporins)
RN  - 0 (Biomarkers)
RN  - 146888-27-9 (Dystroglycans)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Aquaporins/metabolism
MH  - Astrocytes/*metabolism/physiology
MH  - Biomarkers/metabolism
MH  - Blood-Brain Barrier/cytology/*metabolism/physiology/physiopathology
MH  - Cerebrovascular Disorders/*metabolism/pathology
MH  - Dystroglycans/metabolism
MH  - Endothelium, Vascular/*metabolism/physiology
MH  - Humans
MH  - Matrix Metalloproteinases/metabolism
MH  - Neurons/*metabolism/physiology
EDAT- 2014/05/16 06:00
MHDA- 2015/05/27 06:00
CRDT- 2014/05/15 06:00
PHST- 2013/09/09 00:00 [received]
PHST- 2014/03/22 00:00 [accepted]
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - /j/revneuro.ahead-of-print/revneuro-2013-0041/revneuro-2013-0041.xml [pii]
AID - 10.1515/revneuro-2013-0041 [doi]
PST - ppublish
SO  - Rev Neurosci. 2014;25(4):481-507. doi: 10.1515/revneuro-2013-0041.