PMID- 24825101
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20140711
IS  - 1827-1618 (Electronic)
IS  - 0026-4725 (Linking)
VI  - 62
IP  - 4
DP  - 2014 Aug
TI  - The implantable cardioverter defibrillator in congestive heart failure patients 
      in primary prevention: assessment of neuropsychological impact.
PG  - 321-6
AB  - AIM: Cognitive impairment, anxiety and depression have been described in patients 
      with congestive heart failure (CHF). The aim was to analyse the prevalence of 
      cognitive impairment and anxiety-depression in an in-hospital CHF population 
      before discharge attempting to correlate with the presence of an implantable 
      cardioverter defibrillator (ICD). METHODS: All subjects underwent a mini mental 
      state examination (MMSE), geriatric depression scale (GDS), hospital anxiety and 
      depression scale test (HADS). RESULTS: Three-hundred and eighteen CHF patients 
      (age 71.6 years, 195 males) were analysed. The mean New York Heart Association 
      class (NYHA) was 2.9+/-0.8, left ventricular ejection fraction (LVEF) was 
      43.4+/-15.8%; brain natriuretic peptide (BNP) plasma level was 579.8+/-688.4 pg/mL. 
      In 9.6% a pathological MMSE score emerged; a depression of mood in 18.2% and 
      anxiety in 23.4% of patients were observed. An ICD was implanted in 43 (14.2%) 
      CHF patients for primary prevention of cardiac sudden death. Patients in ICD 
      group demonstrated a higher prevalence of renal impairment (creatinine 1.7+/-0.7 
      vs. 1.2+/-0.8 mg/dL; P=0.0001), lower LVEF (24.9+/-8.9 vs. 46.2+/-14.6% P=0.0001) and 
      higher BNP (717.1+/-538 vs. 345.4+/-448.6 pg/ml; P=0.0001) but similar 6-minute 
      walking test (338.6+/-81.3 vs. 345.3+/-114.9 m; P=0.8). An ICD intervention was 
      registered in 9 (20.9%) patients. Although clinical parameters seemed to describe 
      a sicker population in ICD implanted patients, from neuropsychological tests did 
      not emerge any significant differences (P=NS for MMSE, GDS and HADS). CONCLUSION: 
      ICD-implanted CHF patients for primary prevention did not reveal a worsening in 
      anxiety and depression of mood demonstrating a similar cognitive performance in 
      comparison with non-ICD implanted.
FAU - Garnero, S
AU  - Garnero S
AD  - Cardiovascular Rehabilitation‑Heart Failure Unit Ospedale SS Trinita, Fossano, 
      Cuneo, Italy - m_feola@virgilio.it.
FAU - Pomero, A
AU  - Pomero A
FAU - Vallauri, P
AU  - Vallauri P
FAU - Leto, L
AU  - Leto L
FAU - Testa, M
AU  - Testa M
FAU - Feola, M
AU  - Feola M
LA  - eng
PT  - Journal Article
DEP - 20140513
PL  - Italy
TA  - Minerva Cardioangiol
JT  - Minerva cardioangiologica
JID - 0400725
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anxiety/*epidemiology/etiology
MH  - Cognition Disorders/epidemiology/etiology
MH  - Death, Sudden, Cardiac/prevention & control
MH  - Defibrillators, Implantable/*psychology
MH  - Depression/*epidemiology/etiology
MH  - Female
MH  - Heart Failure/*psychology/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prevalence
MH  - Primary Prevention
MH  - Psychiatric Status Rating Scales
EDAT- 2014/05/16 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/05/15 06:00
PHST- 2014/05/15 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - R05Y9999N00A140044 [pii]
PST - ppublish
SO  - Minerva Cardioangiol. 2014 Aug;62(4):321-6. Epub 2014 May 13.