PMID- 24826452
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Feb
TI  - [Aberrant expression of CyclinE and p27 in laryngeal squamous cell carcinoma and 
      the clinical significance].
PG  - 165-9, 174
AB  - OBJECTIVE: To explore new hallmarks affecting the prognosis of patients with 
      laryngeal squamous cell carcinoma (LSCC) via investigating the expression of 
      CyclinE and p27 in LSCC tissues. METHOD: The expression of CyclinE and p27 was 
      detected via Elivision immunohistochemical staining in 160 LSCC tissues and 20 
      normal laryngeal tissues (NLT). The relationship between CyclinE/ p27 and LSCC/ 
      NLT was analyzed via Log-rank analysis. The relationship of CyclinE and p27 
      protein was statistically analyzed by spearman correlation analysis. The 
      relationship between CyclinE/p27 and clinical-pathology-factors of patients with 
      LSCC, such as age, gender, tumor site, diameter, differentiation, lymph node 
      metastasis and PTNM stage were analyzed by Chi-square test. The relationship 
      between clinical-pathology-factors, CyclinE, p27 and overall survival time of 
      patients with LSCC was analyzed via Cox multiplicity and Kaplan-Meier survival 
      analysis. A significant difference was recognized by P<0.05. RESULT: In LSCC the 
      positive rates of CyclinE and p27 protein was 62.50% and 41.25% respectively 
      (P<0.05). In NLT the positive rates of CyclinE and p27 protein was 35% and 70% 
      respectively (P<0.05). The expression of CyclinE or p27 protein was closely 
      correlated with lymph node metastasis, PTNM stage of patients with LSCC (P<0.05). 
      The expression of CyclinE and p27 had no significant correlations with patients' 
      gender, age and tumor site, diameter differentiation (P>0.05 for all). A negative 
      correlation was found between the expression of CyclinE and p27 protein, r= 
      -0.767(P<0.05). Kaplan-Meier survival analysis showed that the overall survival 
      rate of patients with LSCC was 36.9% (P<0.05). The 5-year survival rate in 
      positive group of CyclinE was 8%, in negative group was 80% (P<0.05). On the 
      contrary, the 5-year survival rate of patients with LSCC in positive group of p27 
      protein was 77.27%, the rate was 5.32% in negative group (P<0.05). Cox 
      multivariate regression analysis revealed that lymph node metastasis, PTNM stage, 
      CyclinE and p27 were independent risk factors of prognosis for patients with 
      LSCC. CONCLUSION: It is the molecular basis underlying the development and 
      invasion/ metastasis of LSCC that activation of CyclinE gene accompanying 
      inactivation of p27 gene. It is very important of co-detecting CyclinE and p27 
      protein to predict the prognosis of patients with LSCC.
FAU - Chai, Damin
AU  - Chai D
FAU - Bao, Zhengqi
AU  - Bao Z
FAU - Hu, Jianguo
AU  - Hu J
FAU - Ma, Li
AU  - Ma L
FAU - Feng, Zhenzhong
AU  - Feng Z
FAU - Tao, Yisheng
AU  - Tao Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CCNE1 protein, human)
RN  - 0 (CDKN1B protein, human)
RN  - 0 (Cyclin E)
RN  - 0 (Oncogene Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cyclin E/*metabolism
MH  - Cyclin-Dependent Kinase Inhibitor p27/*metabolism
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Mucosa/metabolism/pathology
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins/*metabolism
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Rate
EDAT- 2014/05/16 06:00
MHDA- 2014/12/23 06:00
CRDT- 2014/05/16 06:00
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Feb;28(3):165-9, 174.