PMID- 24826915
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 51
IP  - 1
DP  - 2015 Feb
TI  - REM sleep deprivation reverses neurochemical and other depressive-like 
      alterations induced by olfactory bulbectomy.
PG  - 349-60
LID - 10.1007/s12035-014-8721-x [doi]
AB  - There is compelling evidence that sleep deprivation (SD) is an effective strategy 
      in promoting antidepressant effects in humans, whereas few studies were performed 
      in relevant animal models of depression. Acute administration of antidepressants 
      in humans and rats generates a quite similar effect, i.e., suppression of rapid 
      eye movement (REM) sleep. Then, we decided to investigate the neurochemical 
      alterations generated by a protocol of rapid eye movement sleep deprivation 
      (REMSD) in the notably known animal model of depression induced by the bilateral 
      olfactory bulbectomy (OBX). REMSD triggered antidepressant mechanisms such as the 
      increment of brain-derived neurotrophic factor (BDNF) levels, within the 
      substantia nigra pars compacta (SNpc), which were strongly correlated to the 
      swimming time (r = 0.83; P < 0.0001) and hippocampal serotonin (5-HT) content 
      (r = 0.66; P = 0.004). Moreover, there was a strong correlation between swimming 
      time and hippocampal 5-HT levels (r = 0.70; P = 0.003), strengthen the notion of 
      an antidepressant effect associated to REMSD in the OBX rats. In addition, REMSD 
      robustly attenuated the hippocampal 5-HT deficiency produced by the OBX 
      procedure. Regarding the rebound (REB) period, we observed the occurrence of a 
      sustained antidepressant effect, indicated mainly by the swimming and climbing 
      times which could be explained by the maintenance of the increased nigral BDNF 
      expression. Hence, hippocampal 5-HT levels remained enhanced in the OBX group 
      after this period. We suggested that the neurochemical complexity inflicted by 
      the OBX model, counteracted by REMSD, is directly correlated to the nigral BDNF 
      expression and hippocampal 5-HT levels. The present findings provide new 
      information regarding the antidepressant mechanisms triggered by REMSD.
FAU - Maturana, Maira J
AU  - Maturana MJ
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, Curitiba, PR, Brazil.
FAU - Pudell, Claudia
AU  - Pudell C
FAU - Targa, Adriano D S
AU  - Targa AD
FAU - Rodrigues, Lais S
AU  - Rodrigues LS
FAU - Noseda, Ana Carolina D
AU  - Noseda AC
FAU - Fortes, Mariana H
AU  - Fortes MH
FAU - Dos Santos, Patricia
AU  - Dos Santos P
FAU - Da Cunha, Claudio
AU  - Da Cunha C
FAU - Zanata, Silvio M
AU  - Zanata SM
FAU - Ferraz, Anete C
AU  - Ferraz AC
FAU - Lima, Marcelo M S
AU  - Lima MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140515
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*complications/pathology/*physiopathology
MH  - Disease Models, Animal
MH  - Hippocampus/metabolism/pathology/physiopathology
MH  - Male
MH  - Metabolome
MH  - Motor Activity/physiology
MH  - Neurotransmitter Agents/*metabolism
MH  - Olfactory Bulb/physiopathology/*surgery
MH  - Rats, Wistar
MH  - Sleep Deprivation/*complications/pathology/*physiopathology
MH  - Sleep, REM/*physiology
MH  - Substantia Nigra/pathology/physiopathology
MH  - Swimming
EDAT- 2014/05/16 06:00
MHDA- 2015/10/21 06:00
CRDT- 2014/05/16 06:00
PHST- 2014/02/05 00:00 [received]
PHST- 2014/04/17 00:00 [accepted]
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - 10.1007/s12035-014-8721-x [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Feb;51(1):349-60. doi: 10.1007/s12035-014-8721-x. Epub 2014 
      May 15.