PMID- 24828055
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20140515
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 6
DP  - 2014 Jun
TI  - Update of the HLA class I eplet database in the website based registry of 
      antibody-defined HLA epitopes.
PG  - 382-90
LID - 10.1111/tan.12322 [doi]
AB  - Eplets are small configurations of polymorphic amino acid residues on human 
      leukocyte antigen (HLA) molecules and are considered as essential components of 
      HLA epitopes recognized by antibodies. This report describes a new design of the 
      eplet repertoire in HLA-ABC alleles used in Luminex kits for antibody testing. 
      There were three steps (1): identify all combinations of polymorphic residues 
      with HLA molecular modeling within a 3-A radius, (2) determine polymorphic 
      residue compositions of 3 A patches from amino acid sequences of HLA alleles in 
      Luminex panels and (3) annotate eplets from one or more patches present on one 
      allele or shared by the same group of alleles. There are now 270 HLA-ABC eplets 
      in the Registry, of which 219 are in antibody-accessible positions on the 
      molecular surface and 51 are defined solely by residue polymorphisms located 
      below the molecular surface. Each eplet has a list of Luminex and non-Luminex 
      alleles for which mismatch acceptability can be determined.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Duquesnoy, R J
AU  - Duquesnoy RJ
AD  - Division of Transplant Pathology, Thomas E. Starzl Tranplantation Institute, 
      University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Complementarity Determining Regions)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Antibody Specificity
MH  - Antigen-Antibody Reactions
MH  - Complementarity Determining Regions/immunology
MH  - Computer Simulation
MH  - *Databases, Protein
MH  - Epitopes/chemistry/*genetics
MH  - *Genes, MHC Class I
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Internet
MH  - Isoantibodies/immunology
MH  - Models, Molecular
MH  - *Polymorphism, Genetic
MH  - Protein Conformation
MH  - *Registries
MH  - Software
OTO - NOTNLM
OT  - HLA-ABC
OT  - epitope
OT  - eplet
OT  - human leukocyte antigen
EDAT- 2014/05/16 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/05/16 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/02/01 00:00 [revised]
PHST- 2014/02/05 00:00 [accepted]
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1111/tan.12322 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Jun;83(6):382-90. doi: 10.1111/tan.12322.