PMID- 24828056
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20140515
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 6
DP  - 2014 Jun
TI  - First report on the antibody verification of HLA-ABC epitopes recorded in the 
      website-based HLA Epitope Registry.
PG  - 391-400
LID - 10.1111/tan.12341 [doi]
AB  - The International Registry of Antibody-Defined HLA Epitopes ( 
      http://www.epregistry.com.br) has been recently established as a tool to 
      understand humoral responses to human leukocyte antigen (HLA) mismatches. These 
      epitopes are defined structurally by three-dimensional molecular modeling and 
      amino acid sequence differences between HLA antigens. So-called eplets represent 
      essential components of HLA epitopes and they are defined by polymorphic 
      residues. A major goal is to identify HLA epitopes that have been verified 
      experimentally with informative antibodies. Our analysis has also included data 
      in many publications. As of 1 November 2013, 95 HLA-ABC antibody-verified 
      epitopes have been recorded, 62 correspond to eplets and 33 are defined by eplets 
      paired with other residue configurations. The Registry is still a 
      work-in-progress and will become a useful resource for HLA professionals 
      interested in histocompatibility testing at the epitope level and investigating 
      antibody responses to HLA mismatches in transplant patients.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Duquesnoy, R J
AU  - Duquesnoy RJ
AD  - Division of Transplant Pathology, Thomas E. Starzl Transplantation Institute, 
      University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
FAU - Marrari, M
AU  - Marrari M
FAU - Mulder, A
AU  - Mulder A
FAU - Sousa, L C D da Mata
AU  - Sousa LC
FAU - da Silva, A S
AU  - da Silva AS
FAU - do Monte, S J H
AU  - do Monte SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Complementarity Determining Regions)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Antibodies, Monoclonal/*immunology
MH  - Antibody Specificity
MH  - Antigen-Antibody Reactions
MH  - Complementarity Determining Regions/immunology
MH  - *Databases, Protein
MH  - Epitopes/chemistry/genetics/*immunology
MH  - *Genes, MHC Class I
MH  - HLA Antigens/chemistry/genetics/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Models, Molecular
MH  - Protein Conformation
MH  - *Registries
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - antibody
OT  - class I
OT  - epitope
OT  - eplet
OT  - human leukocyte antigen
EDAT- 2014/05/16 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/05/16 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/02/01 00:00 [revised]
PHST- 2014/02/20 00:00 [accepted]
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1111/tan.12341 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Jun;83(6):391-400. doi: 10.1111/tan.12341.