PMID- 24828267
OWN - NLM
STAT- MEDLINE
DCOM- 20140703
LR  - 20211021
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 66
IP  - 2
DP  - 2014 Jun 1
TI  - Increased arterial inflammation relates to high-risk coronary plaque morphology 
      in HIV-infected patients.
PG  - 164-71
LID - 10.1097/QAI.0000000000000138 [doi]
AB  - BACKGROUND: Mechanisms predisposing HIV-infected patients to increased 
      cardiovascular disease (CVD) risk remain unclear. OBJECTIVE: To determine the 
      interrelationship between arterial inflammation and high-risk coronary plaque 
      morphology in HIV-infected patients with subclinical coronary atherosclerosis. 
      METHODS: Forty-one HIV-infected patients on stable antiretroviral therapy without 
      known CVD but with atherosclerotic plaque on coronary CT angiography were 
      evaluated with F-FDG-PET. Patients were stratified into 2 groups based on 
      relative degree of arterial inflammation [aortic target-to-background ratio 
      (TBR)]. High-risk coronary atherosclerotic plaque morphology features were 
      compared between groups. RESULTS: HIV-infected patients with higher and lower 
      TBRs were similar with respect to traditional CVD risk parameters. Among 
      HIV-infected patients with higher TBR, an increased percentage of patients 
      demonstrated at least 1 low-attenuation coronary atherosclerotic plaque (40% vs. 
      10%, P = 0.02) and at least 1 coronary atherosclerotic plaque with both low 
      attenuation and positive remodeling (35% vs. 10%, P = 0.04). Moreover, in the 
      higher TBR group, both the number of low-attenuation plaques per patient (P = 
      0.02) and the number of vulnerability features in the most vulnerable plaque (P = 
      0.02) were increased. TBR grouping remained significantly related to the number 
      of low-attenuation plaques/subject (beta = 0.35, P = 0.004), controlling for age, 
      gender, low-density lipoprotein, duration of HIV, and CD4. CONCLUSIONS: These 
      data demonstrate a relationship between arterial inflammation on F-FDG-PET and 
      high-risk coronary atherosclerotic plaque features among HIV-infected patients 
      with subclinical coronary atherosclerosis. Further studies are needed to 
      determine whether arterial inflammation and related high-risk coronary morphology 
      increase the risk of clinical CVD events in the HIV population.
FAU - Tawakol, Ahmed
AU  - Tawakol A
AD  - *Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 
      Boston, MA; daggerProgram in Nutritional Metabolism, Massachusetts General Hospital 
      and Harvard Medical School, Boston, MA; and double daggerCardiovascular Radiology, 
      Massachusetts General Hospital and Harvard Medical School, Boston, MA.
FAU - Lo, Janet
AU  - Lo J
FAU - Zanni, Markella V
AU  - Zanni MV
FAU - Marmarelis, Eleni
AU  - Marmarelis E
FAU - Ihenachor, Ezinne J
AU  - Ihenachor EJ
FAU - MacNabb, Megan
AU  - MacNabb M
FAU - Wai, Bryan
AU  - Wai B
FAU - Hoffmann, Udo
AU  - Hoffmann U
FAU - Abbara, Suhny
AU  - Abbara S
FAU - Grinspoon, Steven
AU  - Grinspoon S
LA  - eng
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
GR  - R01 HL095123/HL/NHLBI NIH HHS/United States
GR  - K23 HL092792/HL/NHLBI NIH HHS/United States
GR  - K24 HL113128/HL/NHLBI NIH HHS/United States
GR  - K23HL092792/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Anti-Retroviral Agents/administration & dosage
MH  - Antiretroviral Therapy, Highly Active
MH  - Arteritis/complications/*diagnosis/diagnostic imaging
MH  - CD4 Lymphocyte Count
MH  - Coronary Angiography
MH  - Coronary Artery Disease/complications/diagnosis/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/complications/*drug therapy
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Plaque, Atherosclerotic/complications/*diagnosis/diagnostic imaging
MH  - Positron-Emission Tomography
MH  - Risk Factors
PMC - PMC4023912
MID - NIHMS571641
EDAT- 2014/05/16 06:00
MHDA- 2014/07/06 06:00
PMCR- 2015/06/01
CRDT- 2014/05/16 06:00
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 00126334-201406010-00008 [pii]
AID - 10.1097/QAI.0000000000000138 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):164-71. doi: 
      10.1097/QAI.0000000000000138.