PMID- 24828407
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20231213
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 5
DP  - 2014
TI  - Does mortality risk of cigarette smoking depend on serum concentrations of 
      persistent organic pollutants? Prospective investigation of the vasculature in 
      Uppsala seniors (PIVUS) study.
PG  - e95937
LID - 10.1371/journal.pone.0095937 [doi]
LID - e95937
AB  - Cigarette smoking is an important cause of preventable death globally, but 
      associations between smoking and mortality vary substantially across country and 
      calendar time. Although methodological biases have been discussed, it is 
      biologically plausible that persistent organic pollutants (POPs) like 
      polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides can affect 
      this association. This study was performed to evaluate if associations of 
      cigarette smoking with mortality were modified by serum concentrations of PCBs 
      and OC pesticides. We evaluated cigarette smoking in 111 total deaths among 986 
      men and women aged 70 years in the Prospective Investigation of the Vasculature 
      in Uppsala Seniors (PIVUS) with mean follow-up for 7.7 years. The association 
      between cigarette smoking and total mortality depended on serum concentration of 
      PCBs and OC pesticides (P value for interaction = 0.02). Among participants in 
      the highest tertile of the serum POPs summary score, former and current smokers 
      had 3.7 (95% CI, 1.5-9.3) and 6.4 (95% CI, 2.3-17.7) times higher mortality 
      hazard, respectively, than never smokers. In contrast, the association between 
      cigarette smoking and total mortality among participants in the lowest tertile of 
      the serum POPs summary score was much weaker and statistically non-significant. 
      The strong smoking-mortality association observed among elderly people with high 
      POPs was mainly driven by low risk of mortality among never smokers with high 
      POPs. As smoking is increasing in many low-income and middle-income countries and 
      POPs contamination is a continuing problem in these areas, the interactions 
      between these two important health-related issues should be considered in future 
      research.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea; BK21 Plus KNU Biomedical Convergence Program, 
      Department of Biomedical Science, Kyungpook National University, Daegu, Korea.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University 
      Hospital, Uppsala, Sweden.
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, Minnesota, United States of America; 
      Department of Nutrition, University of Oslo, Oslo, Norway.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - van Bavel, Bert
AU  - van Bavel B
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140514
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Dioxins/blood
MH  - *Environmental Exposure
MH  - Environmental Pollutants/blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk
MH  - Smoking/adverse effects/*blood/*mortality
MH  - Sweden/epidemiology
MH  - Nicotiana/adverse effects
PMC - PMC4020745
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/05/16 06:00
MHDA- 2014/12/31 06:00
PMCR- 2014/05/14
CRDT- 2014/05/16 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/04/02 00:00 [accepted]
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
PHST- 2014/05/14 00:00 [pmc-release]
AID - PONE-D-13-54236 [pii]
AID - 10.1371/journal.pone.0095937 [doi]
PST - epublish
SO  - PLoS One. 2014 May 14;9(5):e95937. doi: 10.1371/journal.pone.0095937. eCollection 
      2014.