PMID- 24828537
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20220316
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 24
IP  - 9
DP  - 2014 Sep
TI  - Comparison of acquisition time and dose for late gadolinium enhancement imaging 
      at 3.0 T in patients with chronic myocardial infarction using Gd-BOPTA.
PG  - 2192-200
LID - 10.1007/s00330-014-3213-y [doi]
AB  - OBJECTIVES: To compare contrast doses and acquisition times for late gadolinium 
      enhancement (LGE) imaging at 3.0 T using gadobenate dimeglumine (Gd-BOPTA) in 
      patients with chronic myocardial infarction. METHODS: Thirty-four patients with 
      chronic myocardial infarction were randomised to 0.10, 0.15 and 0.20 mmol/kg of 
      Gd-BOPTA. T1-weighted inversion recovery gradient echo sequences were performed 
      at 5, 10, 15 and 20 min post-administration of contrast in a 3.0-T scanner. 
      Scar-to-myocardium contrast-to-noise ratio (CNR), scar-to-blood CNR, scar size 
      and image quality were assessed. RESULTS: Imaging at 5 min was associated with a 
      lower scar-to-blood CNR in comparison to 10, 15 and 20 min at 0.10 mmol/kg, and 
      in comparison to 15 and 20 min at 0.20 mmol/kg. At 0.10-mmol/kg, imaging at 5 min 
      yielded smaller infarct sizes in comparison to 15 and 20 min. Finally, at 
      0.20-mmol/kg, imaging at 5 min was associated with poorer image quality in 
      comparison to later times. CONCLUSIONS: In LGE imaging at 3.0 T, low doses of 
      Gd-BOPTA perform equally well as higher doses. Early acquisition (5 min) is 
      associated with lower infarct sizes and image quality. Studies with sufficient 
      diagnostic quality can be obtained after 10 min using 0.10 mmol/kg Gd-BOPTA. KEY 
      POINTS: Good performance of low Gd-BOPTA doses for LGE imaging at 3.0 T. Imaging 
      at 5 min yields lower contrast, infarct sizes and image quality. Diagnostic 
      quality can be obtained after 10 min using 0.10-mmol/kg Gd-BOPTA.
FAU - Doltra, A
AU  - Doltra A
AD  - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, 
      Augustenburger Platz 1, 13353, Berlin, Germany.
FAU - Skorin, A
AU  - Skorin A
FAU - Hamdan, A
AU  - Hamdan A
FAU - Schnackenburg, B
AU  - Schnackenburg B
FAU - Gebker, R
AU  - Gebker R
FAU - Klein, C
AU  - Klein C
FAU - Nagel, E
AU  - Nagel E
FAU - Fleck, E
AU  - Fleck E
FAU - Kelle, S
AU  - Kelle S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140515
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Contrast Media/administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Electrocardiography
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Meglumine/administration & dosage/*analogs & derivatives
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - Myocardium/*pathology
MH  - *Organometallic Compounds/administration & dosage
MH  - ROC Curve
MH  - Severity of Illness Index
EDAT- 2014/05/16 06:00
MHDA- 2015/05/27 06:00
CRDT- 2014/05/16 06:00
PHST- 2014/01/05 00:00 [received]
PHST- 2014/04/30 00:00 [accepted]
PHST- 2014/03/13 00:00 [revised]
PHST- 2014/05/16 06:00 [entrez]
PHST- 2014/05/16 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - 10.1007/s00330-014-3213-y [doi]
PST - ppublish
SO  - Eur Radiol. 2014 Sep;24(9):2192-200. doi: 10.1007/s00330-014-3213-y. Epub 2014 
      May 15.