PMID- 24830679
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20141018
IS  - 1747-4132 (Electronic)
IS  - 1747-4124 (Linking)
VI  - 8
IP  - 8
DP  - 2014 Nov
TI  - Eosinophilic esophagitis: a practical approach to diagnosis and management.
PG  - 925-34
LID - 10.1586/17474124.2014.919851 [doi]
AB  - Eosinophilic esophagitis (EoE) has emerged as a common cause of dysphagia and 
      food impaction in children and adults. A trial of proton pump inhibitor (PPI) 
      therapy is a mandatory diagnostic first step, given that at least one third of 
      patients with suspected EoE will have PPI-responsive esophageal eosinophilia. 
      Once EoE is diagnosed, short-and long-term therapeutic decision making may rely 
      on patient symptoms, phenotype (inflammatory vs fibrostenotic) and preferences. 
      Currently, the most reliable therapeutic targets are mucosal healing and caliber 
      abnormalities resolution. Topical steroids followed by endoscopic dilation are 
      recommended in symptomatic narrow caliber esophagus/strictures, whereas either 
      topical steroids or dietary therapy are good short-term options for mucosal 
      inflammation. Maintenance anti-inflammatory therapy is necessary to prevent 
      esophageal fibrotic remodeling and stricture formation.
FAU - Molina-Infante, Javier
AU  - Molina-Infante J
AD  - Department of Gastroenterology, Hospital San Pedro de Alcantara, C/ Pablo Naranjo 
      s/n 10003, Caceres, Spain.
FAU - Lucendo, Alfredo J
AU  - Lucendo AJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140516
PL  - England
TA  - Expert Rev Gastroenterol Hepatol
JT  - Expert review of gastroenterology & hepatology
JID - 101278199
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Dilatation/*methods
MH  - Eosinophilic Esophagitis/*diagnosis/etiology/*therapy
MH  - *Esophagoscopy
MH  - Humans
MH  - Proton Pump Inhibitors/*therapeutic use
OTO - NOTNLM
OT  - eosinophilic esophagitis
OT  - esophageal stricture
OT  - proton pump inhibitor-responsive esophageal eosinophilia
OT  - six-food elimination diet
OT  - topical steroids
EDAT- 2014/05/17 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/05/17 06:00
PHST- 2014/05/17 06:00 [entrez]
PHST- 2014/05/17 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - 10.1586/17474124.2014.919851 [doi]
PST - ppublish
SO  - Expert Rev Gastroenterol Hepatol. 2014 Nov;8(8):925-34. doi: 
      10.1586/17474124.2014.919851. Epub 2014 May 16.