PMID- 24833633
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20181217
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 52
IP  - Pt 2
DP  - 2015 Mar
TI  - Insulin resistance and brain-derived neurotrophic factor levels in chronic kidney 
      disease.
PG  - 213-9
LID - 10.1177/0004563214533514 [doi]
AB  - INTRODUCTION: Insulin resistance is a frequent abnormality in chronic kidney 
      disease (CKD) appearing in early stages. Factors known to promote insulin 
      resistance in CKD patients include disorders of ion and acid-base equilibrium and 
      circulating uremia toxins. Recent research has focused on the central nervous 
      system as the source of the brain-derived neurotrophic factor (BDNF). The aim of 
      our work was to study plasma BDNF concentrations in stage 3 and 4 CKD patients in 
      relationship with insulin resistance and distribution of adipose tissue. METHOD: 
      Plasma BDNF concentrations were measured in a study group of 31 patients, 
      including a subgroup of 20 non-diabetic subjects. Additionally dual-energy X-ray 
      absorptiometry (DXA) was performed. Homeostatic model assessment of insulin 
      resistance (HOMA-IR) and homeostatic model assessment of B-cell function 
      (HOMA-beta) indices were calculated. RESULTS: Two separate analyses were 
      performed. In the first analysis performed in all 31 CKD patients, there were no 
      correlations between BDNF and: body mass index (BMI), android, gynoid fat 
      distribution, HOMA-IR and HOMA-beta. In the second analysis performed in 20 CKD 
      patients without diabetes, BDNF was negatively related to gynoid fat (Rs = -0.47, 
      P = 0.034) and women revealed significantly lower levels of BDNF than men 
      (P = 0.046). Normotensive patients disclosed significantly higher BDNF levels 
      than hypertensive patients in the whole CKD group (P = 0.039) and in the 
      non-diabetic subgroup (P = 0.028). No correlations between BDNF and eGFR were 
      found. CONCLUSIONS: Female sex and arterial hypertension are associated with 
      lower BDNF plasma concentration in CKD patients.
CI  - (c) The Author(s) 2014 Reprints and permissions: 
      sagepub.co.uk/journalsPermissions.nav.
FAU - Marchelek-Mysliwiec, Malgorzata
AU  - Marchelek-Mysliwiec M
AD  - Department of Nephrology, Transplantology and Internal Diseases, Pomeranian 
      Medical University, Poland malgorzata.marchelek@gmail.com.
FAU - Cichocka, Ewa
AU  - Cichocka E
AD  - Department of Nephrology, Transplantology and Internal Diseases, Pomeranian 
      Medical University, Poland.
FAU - Dziedziejko, Violetta
AU  - Dziedziejko V
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      Poland.
FAU - Dutkiewicz, Gra Z Yna
AU  - Dutkiewicz GZ
AD  - Department of Nephrology, Transplantology and Internal Diseases, Pomeranian 
      Medical University, Poland.
FAU - Stepniewska, Joanna
AU  - Stepniewska J
AD  - Department of Nephrology, Transplantology and Internal Diseases, Pomeranian 
      Medical University, Poland.
FAU - Safranow, Krzysztof
AU  - Safranow K
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      Poland.
FAU - Budkowska, Marta
AU  - Budkowska M
AD  - Department of Medical Analytics, Pomeranian Medical University, Poland.
FAU - Salata, Daria
AU  - Salata D
AD  - Department of Medical Analytics, Pomeranian Medical University, Poland.
FAU - Syrenicz, Anhelli
AU  - Syrenicz A
AD  - Department of Endocrinology, Pomeranian Medical University, Poland.
FAU - Machalinski, Boguslaw
AU  - Machalinski B
AD  - Department of Pathology, Pomeranian Medical University, Poland.
FAU - Ciechanowski, Kazimierz
AU  - Ciechanowski K
AD  - Department of Nephrology, Transplantology and Internal Diseases, Pomeranian 
      Medical University, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140515
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adiposity
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Nephropathies/complications/epidemiology/metabolism/physiopathology
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Hypertension/complications
MH  - Insulin/blood/metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/metabolism
MH  - Intra-Abdominal Fat/metabolism
MH  - Male
MH  - Middle Aged
MH  - Poland/epidemiology
MH  - Renal Insufficiency, 
      Chronic/complications/epidemiology/*metabolism/physiopathology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Characteristics
OTO - NOTNLM
OT  - Renal disease
OT  - clinical studies
OT  - endocrinology
EDAT- 2014/05/17 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/05/17 06:00
PHST- 2014/05/17 06:00 [entrez]
PHST- 2014/05/17 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 0004563214533514 [pii]
AID - 10.1177/0004563214533514 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2015 Mar;52(Pt 2):213-9. doi: 10.1177/0004563214533514. Epub 
      2014 May 15.