PMID- 24833765
OWN - NLM
STAT- MEDLINE
DCOM- 20150617
LR  - 20140901
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 44
IP  - 3
DP  - 2014 Sep
TI  - Prognostic value of exercise pulmonary haemodynamics in pulmonary arterial 
      hypertension.
PG  - 704-13
LID - 10.1183/09031936.00153613 [doi]
AB  - The aim of the study was to investigate the prognostic value of right heart 
      catheterisation variables measured during exercise. 55 incident patients with 
      idiopathic, familial or anorexigen-associated pulmonary arterial hypertension 
      (PAH) underwent right heart catheterisation at rest and during exercise and 6-min 
      walk testing before PAH treatment initiation. Patients were treated according to 
      recommendations within the next 2 weeks. Right heart catheterisation was repeated 
      3-5 months into the PAH treatment in 20 patients. Exercise cardiac index 
      decreased gradually as New York Heart Association (NYHA) functional class 
      increased whereas cardiac index at rest was not significantly different across 
      NYHA groups. Baseline 6-min walk distance correlated significantly with exercise 
      and change in cardiac index from rest to exercise (r=0.414 and r=0.481, 
      respectively; p<0.01). Change in 6-min walk distance from baseline to 3-5 months 
      under PAH treatment was highly correlated with change in exercise cardiac index 
      (r=0.746, p<0.001). The most significant baseline covariates associated with 
      survival were change in systolic pulmonary artery pressure from rest to exercise 
      and exercise cardiac index (hazard ratio 0.56 (95% CI 0.37-0.86) and 0.14 (95% CI 
      0.05-0.43), respectively). Change in pulmonary haemodynamics during exercise is 
      an important tool for assessing disease severity and may help devise optimal 
      treat-to-target strategies.
CI  - (c)ERS 2014.
FAU - Chaouat, Ari
AU  - Chaouat A
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France Universite de Lorraine, INGRES, EA 7298, 
      Vandoeuvre-les-Nancy, France a.chaouat@chu-nancy.fr.
FAU - Sitbon, Olivier
AU  - Sitbon O
AD  - AP-HP, CHU de Bicetre, Service de Pneumologie, Centre de Reference de 
      l'hypertension pulmonaire severe, DHU TORINO, Le Kremlin-Bicetre, France 
      Universite Paris-Sud, INSERM U999, Le Kremlin-Bicetre, France.
FAU - Mercy, Magalie
AU  - Mercy M
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France.
FAU - Poncot-Mongars, Raphaelle
AU  - Poncot-Mongars R
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France.
FAU - Provencher, Steeve
AU  - Provencher S
AD  - Pulmonary Hypertension Research Group, Centre de recherche de l'Institut 
      Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 
      Quebec, QC, Canada.
FAU - Guillaumot, Anne
AU  - Guillaumot A
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France.
FAU - Gomez, Emmanuel
AU  - Gomez E
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France.
FAU - Selton-Suty, Christine
AU  - Selton-Suty C
AD  - CHU Nancy, Departement de Cardiologie, Vandoeuvre-les-Nancy, France.
FAU - Malvestio, Pascale
AU  - Malvestio P
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France.
FAU - Regent, Denis
AU  - Regent D
AD  - CHU Nancy, Pole imagerie/Radiologie, Vandoeuvre-les-Nancy, France.
FAU - Paris, Christophe
AU  - Paris C
AD  - Universite de Lorraine, INGRES, EA 7298, Vandoeuvre-les-Nancy, France CHU Nancy, 
      Pole des specialites medicales/Pathologie Professionnelle, Vandoeuvre-les-Nancy, 
      France.
FAU - Herve, Philippe
AU  - Herve P
AD  - Centre Chirurgical Marie-Lannelongue, Service des Explorations Fonctionnelles, Le 
      Plessis-Robinson, France.
FAU - Chabot, Francois
AU  - Chabot F
AD  - CHU Nancy, Pole des specialites medicales/Departement de Pneumologie, 
      Vandoeuvre-les-Nancy, France Universite de Lorraine, INGRES, EA 7298, 
      Vandoeuvre-les-Nancy, France.
LA  - eng
PT  - Journal Article
DEP - 20140515
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Cardiac Catheterization
MH  - *Exercise
MH  - Exercise Test
MH  - Familial Primary Pulmonary Hypertension/*diagnosis/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
MH  - Walking
EDAT- 2014/05/17 06:00
MHDA- 2015/06/18 06:00
CRDT- 2014/05/17 06:00
PHST- 2014/05/17 06:00 [entrez]
PHST- 2014/05/17 06:00 [pubmed]
PHST- 2015/06/18 06:00 [medline]
AID - 09031936.00153613 [pii]
AID - 10.1183/09031936.00153613 [doi]
PST - ppublish
SO  - Eur Respir J. 2014 Sep;44(3):704-13. doi: 10.1183/09031936.00153613. Epub 2014 
      May 15.