PMID- 24834012
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20211021
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 11
IP  - 6
DP  - 2014
TI  - Risk-factor analysis of poor graft function after allogeneic hematopoietic stem 
      cell transplantation.
PG  - 652-7
LID - 10.7150/ijms.6337 [doi]
AB  - The objective of this study was to investigate the main risk factors for poor 
      graft function (PGF) after allogeneic hematopoietic stem cell transplantation 
      (allo-HSCT), to allow the improvement of transplantation outcomes through 
      preventive measures. Clinical data for 124 patients who received allo-HSCT were 
      analyzed retrospectively. There were 83 males (66.9%) and 41 females (33.1%) with 
      a median age of 28 years (4-60 years). The median follow-up time was 7 months 
      (1-116 months). Factors analyzed included age, gender, disease diagnosis, source 
      of hematopoietic stem cells, donor type, human leukocyte antigen (HLA) matching, 
      conditioning regimen, numbers of infused mononuclear cells and CD34(+) cells, 
      donor-recipient sex and blood-type matching, prophylactic treatment of 
      graft-versus-host disease (GVHD), grades of GVHD, Epstein-Barr virus or 
      cytomegalovirus (CMV) infection, post-transplantation lymphoproliferative 
      disorders and hepatic veno-occlusive disease. Data were analyzed by univariate 
      and multivariate conditional logistic regression analyses. Among the 124 patients 
      who underwent allo-HSCT, 15 developed PGF (12.1%). Univariate logistic regression 
      analysis identified age, donor-recipient blood type and CMV infection (in 30 
      days) as potential risk factors for PGF. Multivariate analysis of factors with 
      P<0.1 in univariate analysis showed that age, donor-recipient blood type and CMV 
      infection (in 30 days) were significant risk factors for PGF. Patients were 
      divided into subgroups based on age <20, 20-30, 30-40, and >40 years. The risk of 
      PGF increased 2.747-fold (odds ratio (OR)=2.625, 95% confidence interval: 
      1.411-5.347) for each increment in age level. Patients with mismatched blood type 
      (OR=4.051) or CMV infection (OR=9.146) had an increased risk of PGF. We conclude 
      that age, donor-recipient blood-type matching and CMV infection are major risk 
      factors for PGF after allo-HSCT.
FAU - Xiao, Yang
AU  - Xiao Y
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Song, Jiayin
AU  - Song J
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Jiang, Zujun
AU  - Jiang Z
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Li, Yonghua
AU  - Li Y
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Gao, Yang
AU  - Gao Y
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Xu, Wenning
AU  - Xu W
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Lu, Ziyuan
AU  - Lu Z
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Wang, Yaochun
AU  - Wang Y
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
FAU - Xiao, Haowen
AU  - Xiao H
AD  - Department of Hematology, Guangzhou General Hospital of Guangzhou Military 
      Command, Guangzhou 510010, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140430
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Blood Grouping and Crossmatching
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/pathogenicity
MH  - Delayed Graft Function/epidemiology/*pathology
MH  - Female
MH  - Graft vs Host Disease/epidemiology/*pathology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Transplantation, Homologous/*adverse effects
PMC - PMC4021098
OTO - NOTNLM
OT  - Allogeneic hematopoietic stem cell transplantation
OT  - Graft-versus-host disease.
OT  - Hematopoietic reconstitution
OT  - Poor graft function
OT  - Risk factor
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2014/05/17 06:00
MHDA- 2014/12/18 06:00
PMCR- 2014/01/01
CRDT- 2014/05/17 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2014/01/20 00:00 [accepted]
PHST- 2014/05/17 06:00 [entrez]
PHST- 2014/05/17 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - ijmsv11p0652 [pii]
AID - 10.7150/ijms.6337 [doi]
PST - epublish
SO  - Int J Med Sci. 2014 Apr 30;11(6):652-7. doi: 10.7150/ijms.6337. eCollection 2014.