PMID- 24834937
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20220330
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 134
IP  - 7
DP  - 2014 Jul
TI  - Dickkopf-1 is a novel prognostic biomarker for laryngeal squamous cell carcinoma.
PG  - 753-9
LID - 10.3109/00016489.2014.894251 [doi]
AB  - CONCLUSIONS: Dickkopf-1 (DKK1) is a novel prognostic biomarker for laryngeal 
      squamous cell carcinoma (LSCC). DKK1 may be a promising strategy for the future 
      treatment of LSCC metastasis and recurrence. OBJECTIVES: DKK1 is reportedly 
      involved in the metastasis and invasion of several tumor types. This study aimed 
      to investigate the prognostic value of DKK1 in LSCC. METHODS: DKK1 expression was 
      measured in Hep-2 cell lines, as well as in tumor and peritumoral tissues, using 
      quantitative real-time PCR and western blot analyses. The role of DKK1 in LSCC 
      was investigated by depleting DKK1 using small interfering RNAs. Tissue 
      microarrays of 102 LSCC patient samples were employed to immunohistochemically 
      detect expression of DKK1, vascular endothelial growth factor C (VEGF-C), and 
      beta-catenin. Prognostic significance was assessed using Kaplan-Meier survival 
      estimates. RESULTS: DKK1 expression was elevated in the Hep-2 cell line and tumor 
      samples. DKK1 depletion decreased cell proliferation, migration, and 
      invasiveness. High DKK1 expression was significantly associated with T and 
      clinical stage, lymph node metastasis, and tumor size (p < 0.05). Increased DKK1 
      levels in LSCC tissues correlated with elevated VEGF-C and beta-catenin. 
      Multivariate analyses revealed that DKK1 was an unfavorable predictor of overall 
      survival.
FAU - Shi, Yong
AU  - Shi Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Fudan University Eye, Ear, 
      Nose, and Throat Hospital , Shanghai.
FAU - Gong, Hong-Li
AU  - Gong HL
FAU - Zhou, Liang
AU  - Zhou L
FAU - Tian, Jie
AU  - Tian J
FAU - Wang, Yang
AU  - Wang Y
LA  - eng
PT  - Journal Article
DEP - 20140519
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DKK1 protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (VEGFC protein, human)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cell Line, Tumor
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality/pathology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Vascular Endothelial Growth Factor C/metabolism
MH  - beta Catenin/metabolism
OTO - NOTNLM
OT  - Dickkopf-1
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
OT  - vascular endothelial growth factor C
OT  - beta-catenin
EDAT- 2014/05/20 06:00
MHDA- 2015/02/11 06:00
CRDT- 2014/05/20 06:00
PHST- 2014/05/20 06:00 [entrez]
PHST- 2014/05/20 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - 10.3109/00016489.2014.894251 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2014 Jul;134(7):753-9. doi: 10.3109/00016489.2014.894251. Epub 
      2014 May 19.