PMID- 24835434
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20220408
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 235
IP  - 1
DP  - 2014 Jul
TI  - The effect of physical activity or exercise on key biomarkers in 
      atherosclerosis--a systematic review.
PG  - 150-61
LID - S0021-9150(14)00226-3 [pii]
LID - 10.1016/j.atherosclerosis.2014.04.026 [doi]
AB  - OBJECTIVE: This systematic review aimed to summarize published papers on the 
      effect of physical activity (PA)/exercise on key atherosclerotic factors in 
      patients with risk factors for or established cardiovascular disease (CVD). 
      METHODS: Studies involving PA and cytokines, chemokines, adhesion molecules, CRP 
      and angiogenic factors were searched for in Medline and Cochrane library. 
      Original human studies of more than 2 weeks of PA intervention were included. 
      Study quality was assessed according to the GRADE system of evidence. RESULTS: 
      Twenty-eight papers fulfilled the inclusion criteria. PA decreases the cytokines, 
      tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interferon-y IFN-y 
      (high, moderate and low evidence, respectively). The effect of PA on chemokines; 
      stromal derived factor-1 (SDF-1), interleukin-8 (IL-8) (insufficient evidence) 
      and monocyte chemoattractant protein-1 (MCP-1) (low evidence) was inconclusive. 
      Aerobic exercise decreased the adhesion molecules, vascular cell adhesion 
      molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) (moderate and 
      high evidence, respectively), while effects of PA on E- and P-selectin were 
      inconclusive. PA decreases C-reactive protein (CRP) (high evidence). The 
      angiogenic actors, endothelial progenitor cells (EPCs) are increased (high 
      evidence) and VEGF is decreased (moderate evidence) by PA. The effect of PA on 
      these factors seems to depend on the type and duration of exercise intervention 
      and patient factors, such as presence of ischemia. CONCLUSION: As presented in 
      this review, there is a high level of evidence that physical activity positively 
      affects key players in atherosclerosis development. These effects could partly 
      explain the scientifically proven anti-atherogenic effects of PA, and do have 
      important clinical implications.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Palmefors, Henning
AU  - Palmefors H
AD  - Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, 
      Goteborg, Sweden.
FAU - DuttaRoy, Smita
AU  - DuttaRoy S
AD  - Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, 
      Goteborg, Sweden.
FAU - Rundqvist, Bengt
AU  - Rundqvist B
AD  - Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, 
      Goteborg, Sweden.
FAU - Borjesson, Mats
AU  - Borjesson M
AD  - Swedish School of Sports and Health Sciences and Department of Cardiology, 
      Karolinska University Hospital, Stockholm, Sweden. Electronic address: 
      mats.brjesson@telia.com.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20140501
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Atherosclerosis/*blood
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/*physiopathology/*prevention & control
MH  - Cell Adhesion
MH  - Chemokine CXCL12/blood
MH  - Cytokines/metabolism
MH  - *Exercise
MH  - Humans
MH  - Inflammation
MH  - Interferon-gamma/blood
MH  - Interleukin-6/blood
MH  - Motor Activity
MH  - Neovascularization, Pathologic
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Exercise
OT  - Molecular biology
OT  - Physical activity
EDAT- 2014/05/20 06:00
MHDA- 2016/05/11 06:00
CRDT- 2014/05/20 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2014/04/12 00:00 [revised]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/05/20 06:00 [entrez]
PHST- 2014/05/20 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
AID - S0021-9150(14)00226-3 [pii]
AID - 10.1016/j.atherosclerosis.2014.04.026 [doi]
PST - ppublish
SO  - Atherosclerosis. 2014 Jul;235(1):150-61. doi: 
      10.1016/j.atherosclerosis.2014.04.026. Epub 2014 May 1.