PMID- 24835642 OWN - NLM STAT- MEDLINE DCOM- 20180117 LR - 20211021 IS - 2325-9574 (Print) IS - 2325-9582 (Electronic) IS - 2325-9574 (Linking) VI - 13 IP - 5 DP - 2014 Sep-Oct TI - Beyond the Brain: The Role of Brain-Derived Neurotrophic Factor in Viroimmune Responses to Antiretroviral Therapy among People Living with HIV with and without Alcohol Use. PG - 454-60 LID - 10.1177/2325957414535253 [doi] AB - OBJECTIVE: Given the emerging data suggesting the key role of brain-derived neurotrophic factor (BDNF) in the immune system, we assessed longitudinally whether BDNF depletions induced by hazardous alcohol use (HAU) would impact a response to antiretroviral therapy (ART). METHODS: In a prospective single-site cohort, virological and immunological responses to ART in 200 hazardous and 200 nonhazardous users were obtained, along with plasma BDNF levels. RESULTS: Hazardous drinkers were more likely to have BDNF levels <4000 pg/mL (odds ratio [OR] = 1.6, P = .01). Participants with BDNF <4000 pg/mL were less likely to have CD4 counts of more than 500 cells/mm(3) (P = .02) and to achieve viral suppression over the follow-up period (OR = 1.5, P = .03). Multivariate analysis confirmed the significant role of HAU and low BDNF in predicting viroimmune responses. CONCLUSION: Hazardous alcohol use was associated with BDNF alterations, which in turn were linked to a limited response to ART in terms of viral suppression and CD4 count improvements. CI - (c) The Author(s) 2014. FAU - Miguez-Burbano, Maria Jose AU - Miguez-Burbano MJ AD - School of Integrated Science and Humanity, Florida International University, Miami, FL, USA mjmiguez@fiu.edu. FAU - Espinoza, Luis AU - Espinoza L AD - Department of Medicine, University of Miami School of Medicine, Miami, FL, USA. FAU - Bueno, Diego AU - Bueno D AD - School of Integrated Science and Humanity, Florida International University, Miami, FL, USA. FAU - Vargas, Mayra AU - Vargas M AD - School of Integrated Science and Humanity, Florida International University, Miami, FL, USA. FAU - Trainor, Allison B AU - Trainor AB AD - Departments of Epidemiology and Medicine, University of Florida, Gainesville, FL, USA. FAU - Quiros, Clery AU - Quiros C AD - School of Integrated Science and Humanity, Florida International University, Miami, FL, USA. FAU - Lewis, John E AU - Lewis JE AD - Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. FAU - Asthana, Deshratn AU - Asthana D AD - Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. LA - eng GR - R01 AA018095/AA/NIAAA NIH HHS/United States GR - U24 AA022002/AA/NIAAA NIH HHS/United States PT - Journal Article DEP - 20140516 PL - United States TA - J Int Assoc Provid AIDS Care JT - Journal of the International Association of Providers of AIDS Care JID - 101603896 RN - 0 (Anti-Retroviral Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - *Alcohol Drinking/blood/epidemiology MH - Anti-Retroviral Agents/*therapeutic use MH - Antiretroviral Therapy, Highly Active MH - Brain-Derived Neurotrophic Factor/*blood MH - CD4 Lymphocyte Count MH - *HIV Infections/drug therapy/epidemiology/immunology/virology MH - HIV-1 MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Viral Load PMC - PMC4508011 MID - NIHMS706243 OTO - NOTNLM OT - BDNF OT - CD4 OT - HIV/AIDS OT - alcohol OT - viral load COIS- Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2014/05/20 06:00 MHDA- 2014/05/20 06:01 PMCR- 2015/09/01 CRDT- 2014/05/20 06:00 PHST- 2014/05/20 06:00 [entrez] PHST- 2014/05/20 06:00 [pubmed] PHST- 2014/05/20 06:01 [medline] PHST- 2015/09/01 00:00 [pmc-release] AID - 2325957414535253 [pii] AID - 10.1177/2325957414535253 [doi] PST - ppublish SO - J Int Assoc Provid AIDS Care. 2014 Sep-Oct;13(5):454-60. doi: 10.1177/2325957414535253. Epub 2014 May 16.