PMID- 24837058
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20211021
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 156
IP  - 2-3
DP  - 2014 Jul
TI  - Impact of substance use on conversion to psychosis in youth at clinical high risk 
      of psychosis.
PG  - 277-80
LID - S0920-9964(14)00193-5 [pii]
LID - 10.1016/j.schres.2014.04.021 [doi]
AB  - Elevated rates of substance use (alcohol, tobacco, cannabis) have been reported 
      in people at clinical high risk (CHR) of developing psychosis and there is some 
      evidence that substance use may be higher in those who convert to a psychosis 
      compared to non-converters. However little is known about the predictive value of 
      substance use on risk of conversion to psychosis in those at CHR of psychosis. In 
      the current study, 170 people at CHR of psychosis were assessed at baseline on 
      severity of alcohol, tobacco and cannabis using the Alcohol and Drug Use Scale. 
      Participants were recruited across three sites over a four year period as part of 
      the Enhancing the Prospective Prediction of Psychosis (PREDICT) study. Predictors 
      of conversion to psychosis were examined using Cox proportional hazards models. 
      Results revealed that low use of alcohol, but neither cannabis use nor tobacco 
      use at baseline, contributed to the prediction of psychosis in the CHR sample. 
      Prediction algorithms incorporating combinations of additional baseline variables 
      known to be associated with psychotic conversion may result in increased 
      predictive power compared with substance use alone.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Buchy, Lisa
AU  - Buchy L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Perkins, Diana
AU  - Perkins D
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United 
      States.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, United States.
FAU - Liu, Lu
AU  - Liu L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada. Electronic address: jmadding@ucalgary.ca.
LA  - eng
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01MH066134/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
DEP - 20140514
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alcohol-Related Disorders/complications
MH  - Algorithms
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Marijuana Abuse/complications
MH  - Prodromal Symptoms
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Psychotic Disorders/*complications/*diagnosis
MH  - Risk
MH  - Substance-Related Disorders/*complications
MH  - Tobacco Use Disorder/complications
MH  - Young Adult
PMC - PMC4082820
MID - NIHMS591016
OTO - NOTNLM
OT  - Alcohol
OT  - Cannabis
OT  - Prodrome
OT  - Psychosis
OT  - Substance use
OT  - Tobacco
COIS- Conflict of Interest All authors declare no conflict of interest.
EDAT- 2014/05/20 06:00
MHDA- 2015/01/21 06:00
PMCR- 2015/07/01
CRDT- 2014/05/20 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2014/04/10 00:00 [revised]
PHST- 2014/04/17 00:00 [accepted]
PHST- 2014/05/20 06:00 [entrez]
PHST- 2014/05/20 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - S0920-9964(14)00193-5 [pii]
AID - 10.1016/j.schres.2014.04.021 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Jul;156(2-3):277-80. doi: 10.1016/j.schres.2014.04.021. Epub 
      2014 May 14.