PMID- 24837163
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20181202
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 69
DP  - 2014 Aug
TI  - Persistent organic pollutants and children's respiratory health: the role of 
      cytokines and inflammatory biomarkers.
PG  - 133-40
LID - S0160-4120(14)00141-X [pii]
LID - 10.1016/j.envint.2014.04.021 [doi]
AB  - Evidence of adverse effects of persistent organic pollutants (POPs) on the 
      developmental respiratory and immune systems in children is still limited, and 
      the biological mechanisms behind such effects are not fully understood. The aim 
      of the present study is to evaluate the effects of prenatal DDE, HCB and SigmaPCB 
      exposure on children's respiratory health from birth to 14 years and to evaluate 
      the role of immune biomarkers in these associations. We measured prenatal DDE, 
      HCB and SigmaPCB levels in 405 participants of the INMA-Menorca birth cohort (Spain) 
      and collected information on wheeze, chest infections, atopy and asthma from 
      birth until the age of 14 years. At age 4 years, 275 children provided serum 
      samples and IL6, IL8, IL10, TNFalpha and C-reactive protein were measured. We applied 
      linear and logistic regression models and generalized estimating equations. 
      Prenatal DDE was associated with wheeze at age 4 years [RR (95% CI) per doubling 
      of concentration=1.35 (1.07, 1.71)], but not thereafter. Prenatal HCB was 
      associated with wheeze [1.58 (1.04, 2.41)] and chest infections [1.89 (1.10, 
      3.25)] at age 10years. No associations were found with SigmaPCBs. IL10 levels 
      increased with increasing POP concentration, with HCB showing the strongest 
      association [beta (95% CI)=0.22 (0.02, 0.41)]. IL8, IL10 and TNFalpha were associated 
      with wheeze and/or chest infections and IL10 was associated with asthma. Prenatal 
      DDE and HCB exposure was associated with respiratory health of children at 
      different ages. This study further suggests a possible role of IL10, but not of 
      the other immune biomarkers examined, as an early marker of chronic 
      immune-related health effects of POPs.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Gascon, Mireia
AU  - Gascon M
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: 
      mgascon@creal.cat.
FAU - Sunyer, Jordi
AU  - Sunyer J
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain; IMIM (Hospital del Mar Medical 
      Research Institute), Barcelona, Catalonia, Spain. Electronic address: 
      jsunyer@creal.cat.
FAU - Martinez, David
AU  - Martinez D
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: 
      dmartinez@creal.cat.
FAU - Guerra, Stefano
AU  - Guerra S
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: 
      sguerra@creal.cat.
FAU - Lavi, Iris
AU  - Lavi I
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: 
      ilavi@creal.cat.
FAU - Torrent, Maties
AU  - Torrent M
AD  - Area de Salut de Menorca, IB-SALUT, Mallorca, Spain; Fundacio Caubet-CIMERA, 
      Mallorca, Spain. Electronic address: maties.torrent@ssib.es.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, 
      Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER 
      Epidemiologia y Salud Publica (CIBERESP), Spain. Electronic address: 
      mvrijheid@creal.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140516
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Age Factors
MH  - Asthma/epidemiology/immunology
MH  - Biomarkers/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cytokines/immunology/*metabolism
MH  - Dichlorodiphenyl Dichloroethylene/blood/*toxicity
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hexachlorobenzene/blood/*toxicity
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology/immunology
MH  - Prevalence
MH  - Respiratory Sounds/immunology
MH  - Respiratory Tract Diseases/*epidemiology/immunology
MH  - Respiratory Tract Infections/epidemiology/immunology
MH  - Spain/epidemiology
OTO - NOTNLM
OT  - Asthma
OT  - Chest infections
OT  - Children
OT  - Cytokines
OT  - Persistent organic pollutants (POPs)
OT  - Wheeze
EDAT- 2014/05/20 06:00
MHDA- 2014/09/30 06:00
CRDT- 2014/05/20 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2014/04/23 00:00 [revised]
PHST- 2014/04/29 00:00 [accepted]
PHST- 2014/05/20 06:00 [entrez]
PHST- 2014/05/20 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - S0160-4120(14)00141-X [pii]
AID - 10.1016/j.envint.2014.04.021 [doi]
PST - ppublish
SO  - Environ Int. 2014 Aug;69:133-40. doi: 10.1016/j.envint.2014.04.021. Epub 2014 May 
      16.