PMID- 24838976
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 26
IP  - 5
DP  - 2014 May
TI  - The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 
      Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings.
PG  - 1981-1991
AB  - CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both 
      plants and animals. In dark-grown Arabidopsis thaliana seedlings, COP1 targets 
      photomorphogenesis-promoting factors for degradation to repress 
      photomorphogenesis. Little is known, however, about how COP1 itself is regulated. 
      Here, we identify COP1 SUPPRESSOR1 (CSU1), a RING-finger E3 ubiquitin ligase, as 
      a regulator of COP1. Genetic evidence demonstrates that csu1 mutations suppress 
      cop1-6 phenotypes completely in the dark. Furthermore, CSU1 colocalizes with COP1 
      in nuclear speckles and negatively regulates COP1 protein accumulation in 
      darkness. CSU1 can ubiquitinate COP1 in vitro and is essential for COP1 
      ubiquitination in vivo. Therefore, we conclude that CSU1 plays a major role in 
      maintaining COP1 homeostasis by targeting COP1 for ubiquitination and degradation 
      in dark-grown seedlings.
CI  - (c) 2014 American Society of Plant Biologists. All rights reserved.
FAU - Xu, Dongqing
AU  - Xu D
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China Department of Biological and Environmental Sciences, Gothenburg University, 
      SE-405 30 Gothenburg, Sweden.
FAU - Lin, Fang
AU  - Lin F
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China Department of Biological and Environmental Sciences, Gothenburg University, 
      SE-405 30 Gothenburg, Sweden.
FAU - Huang, Xi
AU  - Huang X
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China.
FAU - Li, Jigang
AU  - Li J
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing 100193, China.
FAU - Ling, Junjie
AU  - Ling J
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China.
FAU - Hettiarachchi, Chamari
AU  - Hettiarachchi C
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      SE-405 30 Gothenburg, Sweden.
FAU - Tellgren-Roth, Christian
AU  - Tellgren-Roth C
AD  - Uppsala Genome Center, National Genomics Infrastructure-Science for Life 
      Laboratory, Department of Immunology, Genetics, and Pathology, Uppsala 
      University, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden.
FAU - Holm, Magnus
AU  - Holm M
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      SE-405 30 Gothenburg, Sweden.
FAU - Deng, Xing Wang
AU  - Deng XW
AD  - Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, 
      State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center 
      for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, 
      China Department of Molecular, Cellular, and Developmental Biology, Yale 
      University, New Haven, Connecticut 06520 xingwang.deng@yale.edu.
LA  - eng
GR  - R01 GM047850/GM/NIGMS NIH HHS/United States
GR  - R37 GM047850/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20140516
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
PMC - PMC4079363
EDAT- 2014/05/20 06:00
MHDA- 2014/05/20 06:01
PMCR- 2014/05/16
CRDT- 2014/05/20 06:00
PHST- 2014/05/20 06:00 [entrez]
PHST- 2014/05/20 06:00 [pubmed]
PHST- 2014/05/20 06:01 [medline]
PHST- 2014/05/16 00:00 [pmc-release]
AID - tpc.114.124024 [pii]
AID - 124024 [pii]
AID - 10.1105/tpc.114.124024 [doi]
PST - ppublish
SO  - Plant Cell. 2014 May;26(5):1981-1991. doi: 10.1105/tpc.114.124024. Epub 2014 May 
      16.