PMID- 24840376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20220409
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 20
IP  - 2
DP  - 2014 Apr 30
TI  - Prevalence of Anti-deamidated Gliadin Peptide Antibodies in Asian Patients With 
      Irritable Bowel Syndrome.
PG  - 236-41
LID - 10.5056/jnm.2014.20.2.236 [doi]
AB  - BACKGROUND/AIMS: Non-celiac gluten sensitivity has been increasingly recognized 
      as a predisposing factor for irritable bowel syndrome (IBS)-like symptoms in 
      Western populations where celiac disease (CD) is relatively common. In Asia where 
      CD is rare, we wish to de-termine the prevalence of gluten protein associated 
      serology in IBS patients, which has not been formally studied, and its rela-tion 
      to histological and human leukocyte antigen (HLA) markers. METHODS: We reviewed a 
      consecutive cohort of Asian patients with IBS, who had undergone serologic 
      testing for IgA against deamidated gliadin peptide antibodies (IgA DGP) and IgA 
      anti-endomysium antibodies, and who also had duodenal biopsies during clinical 
      workup. In addition, a subset of Chinese patients with positive serology was 
      further tested for HLA-DQ2 and HLA-DQ8. RESULTS: Of 186 patients, 34 (18%) were 
      positive for IgA DGP; bloating, abdominal pain, belching and diarrhea were the 
      most com-monly reported symptoms but diarrhea as the most bothersome symptom was 
      significantly more common in IgA DGP positive patients. Mildly increased 
      intra-epithelial lymphocytes on duodenal biopsy was also more common (29% vs. 9%, 
      P = 0.001). Nine of 21 Chinese patients tested as IgA DGP positive undertook 
      HLA-DQ2/DQ8 testing, with only 2 being positive for HLA-DQ8. All patients with 
      positive IgA DGP reported symptom improvement with gluten withdrawal. 
      CONCLUSIONS: We have described a series of Asian, mainly Chinese, patients with 
      IBS who were tested positive for IgA DGP, and improved on a gluten exclusion 
      diet. We believe this is the first report of non-celiac gluten sensitivity in 
      Asia, a region where CD is uncommon.
FAU - Lu, Wei
AU  - Lu W
AD  - Department of Gastroenterolgy and Hepatology, National University Health System, 
      Singapore.
FAU - Gwee, Kok-Ann
AU  - Gwee KA
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore.
FAU - Siah, Kewin Tien Ho
AU  - Siah KT
AD  - Department of Gastroenterolgy and Hepatology, National University Health System, 
      Singapore.
FAU - Kang, Jin Yong
AU  - Kang JY
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore.
FAU - Lee, Rumin
AU  - Lee R
AD  - Stomach, Liver and Bowel Center, Gleneagles Hospital, Singapore.
FAU - Ngan, Cecilia Cheng Lai
AU  - Ngan CC
AD  - Department of Pathology, Singapore General Hospital, Singapore.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC4015193
OTO - NOTNLM
OT  - Asian
OT  - Celiac disease
OT  - Gliadin
OT  - Gluten sensitive enteropathy
OT  - Irritable bowel syndrome
EDAT- 2014/05/21 06:00
MHDA- 2014/05/21 06:01
PMCR- 2014/04/01
CRDT- 2014/05/21 06:00
PHST- 2013/11/15 00:00 [received]
PHST- 2013/12/27 00:00 [revised]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/05/21 06:00 [entrez]
PHST- 2014/05/21 06:00 [pubmed]
PHST- 2014/05/21 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - jnm.2014.20.2.236 [pii]
AID - jnm-20-236 [pii]
AID - 10.5056/jnm.2014.20.2.236 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2014 Apr 30;20(2):236-41. doi: 
      10.5056/jnm.2014.20.2.236.