PMID- 2484202
OWN - NLM
STAT- MEDLINE
DCOM- 19900904
LR  - 20190918
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 21
IP  - 3-4
DP  - 1989 Nov-Dec
TI  - Regulation of immunity to extraembryonic antigens in human pregnancy.
PG  - 76-81
AB  - Pregnancy results in the immunologic challenge of the female to a wide variety of 
      allogeneic antigens. Particular attention has been given to antibodies directed 
      to allotypic trophoblast antigens (TLX), for trophoblast form the true allograft 
      interface between mother and fetus. Studies found that antibodies to paternal TLX 
      allotypes are produced in women suffering from secondary recurrent abortions. 
      These TLX antibodies are not directed to classical HLA private epitopes. In this 
      report, treatment of lymphocytes with papain to remove HLA Class I did not 
      decrease TLX antigen densities. These results suggest TLX antibodies are not 
      directed to Class I epitopes, public or private. The allotypic nature of TLX 
      antigens requires that a pregnant female must be able to regulate TLX immune 
      responses to avoid rejection of the conceptus. One mechanism to specifically and 
      systemically regulate TLX immunity is the idiotype anti-idiotype network. We 
      provide preliminary evidence in this report for the presence of TLX idiotype 
      network in a normal primigravida. Initially, no antipaternal TLX antibodies were 
      detected in the serum of the primigravida, suggesting no TLX immunization had 
      occurred. However, separation of Ab1 from Ab2 by absorption of primigravida serum 
      with 2 degrees aborter Ab1 resulted in seroconversion. The primigravida's Ab1 was 
      cytotoxic for paternal and 3rd-party lymphocytes in a non-HLA-restricted pattern. 
      Primigravida's Ab2 was recovered from the Ab1 matrix by competitive elution by 
      using platelets as source of TLX antigen. The Ab2 was found to inhibit 
      cytotoxicity by 2 degrees aborter Ab1 as well as primigravida Ab1. This is 
      evidence that the Ab2 recognizes a cross-reactive idiotype (CRI) on TLX 
      antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Torry, D S
AU  - Torry DS
AD  - Center for Reproduction and Transplantation Immunology, Methodist Hospital of 
      Indiana, Indianapolis 46205.
FAU - Faulk, W P
AU  - Faulk WP
FAU - McIntyre, J A
AU  - McIntyre JA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Autoantigens)
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin Idiotypes)
RN  - 0 (Isoantigens)
RN  - 0 (trophoblast-lymphocyte cross-reactive antigens)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/immunology
MH  - Autoantigens/*immunology
MH  - Epitopes/immunology
MH  - Female
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Immunoglobulin Idiotypes/immunology
MH  - Isoantigens/*immunology
MH  - Lymphocytes/immunology
MH  - Pregnancy/*immunology
MH  - Trophoblasts/immunology
RF  - 29
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1111/j.1600-0897.1989.tb01007.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 1989 Nov-Dec;21(3-4):76-81. doi: 
      10.1111/j.1600-0897.1989.tb01007.x.