PMID- 24843376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 11
IP  - 2
DP  - 2014 Apr
TI  - Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder.
PG  - 192-9
LID - 10.4306/pi.2014.11.2.192 [doi]
AB  - OBJECTIVE: We investigated possible association between depressive disorders and 
      BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and 
      serotonin transporter (SLC6A4) gene are promising candidate genes for depressive 
      disorders. It has been suggested that BDNF promotes the survival and 
      differentiation of serotonergic neurons and that serotonergic transmission exerts 
      powerful control over BDNF gene expression. METHODS: Final analyses were 
      performed on 186 patients with depressive disorders and 1032 controls. Val66Met 
      polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene 
      were genotyped and allele and genotypic associations on the diagnosis of 
      depression and age at onset of depression were analyzed. RESULTS: The 5-HTTLPR 
      was positively associated with depressive affected status in the total sample and 
      in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, 
      not in males. The BDNF Val66Met showed no association with depression. BDNF 
      Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. 
      Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a 
      significant association with age at onset of depression in the entire patient 
      group. This association was also found in the female but not in the male patient 
      group. None of the positive results survived Bonferroni correction for multiple 
      testing. CONCLUSION: This result suggested that BDNF Val66Met and 5-HTTLPR may 
      contribute to depressive disorders in a complex way and that the genetic effect 
      could differ by gender. Further studies with large number of patients will be 
      necessary.
FAU - Lee, Kyu Young
AU  - Lee KY
AD  - Department of Neuropsychiatry, Eulji University School of Medicine, Daejeon, 
      Republic of Korea. ; Department of Psychiatry, Eulji General Hospital, Seoul, 
      Republic of Korea.
FAU - Jeong, Seong Hoon
AU  - Jeong SH
AD  - Department of Neuropsychiatry, Eulji University School of Medicine, Daejeon, 
      Republic of Korea. ; Department of Psychiatry, Eulji University Hospital, 
      Daejeon, Republic of Korea.
FAU - Kim, Se Hyun
AU  - Kim SH
AD  - Institute of Human Behavioral Medicine, Medical Research Institute, Seoul 
      National University, Seoul, Republic of Korea.
FAU - Ahn, Yong Min
AU  - Ahn YM
AD  - Institute of Human Behavioral Medicine, Medical Research Institute, Seoul 
      National University, Seoul, Republic of Korea. ; Department of Psychiatry and 
      Behavioral Science, Seoul National University College of Medicine, Seoul, 
      Republic of Korea. ; Department of Neuropsychiatry, Seoul National University 
      Hospital, Seoul, Republic of Korea. ; Biomedical Research Institute, Seoul 
      National University Hospital, Seoul, Republic of Korea.
FAU - Kim, Yong Sik
AU  - Kim YS
AD  - Department of Neuropsychiatry, Dongguk University International Hospital, Dongguk 
      University Medical School, Goyang, Republic of Korea.
FAU - Jung, Hee Yeon
AU  - Jung HY
AD  - Department of Psychiatry and Behavioral Science, Seoul National University 
      College of Medicine, Seoul, Republic of Korea. ; Department of Psychiatry, 
      SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
FAU - Bang, Yang Weon
AU  - Bang YW
AD  - Department of Psychiatry, Keyo Hospital, Uiwang, Republic of Korea.
FAU - Joo, Eun-Jeong
AU  - Joo EJ
AD  - Department of Neuropsychiatry, Eulji University School of Medicine, Daejeon, 
      Republic of Korea. ; Department of Psychiatry, Eulji General Hospital, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20140411
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC4023095
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDNF Val66Met
OT  - Depressive disorder
OT  - Genetic polymorphism
OT  - Onset
OT  - Serotonin transporter
EDAT- 2014/05/21 06:00
MHDA- 2014/05/21 06:01
PMCR- 2014/04/01
CRDT- 2014/05/21 06:00
PHST- 2013/05/10 00:00 [received]
PHST- 2013/06/28 00:00 [revised]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2014/05/21 06:00 [entrez]
PHST- 2014/05/21 06:00 [pubmed]
PHST- 2014/05/21 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.4306/pi.2014.11.2.192 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2014 Apr;11(2):192-9. doi: 10.4306/pi.2014.11.2.192. Epub 
      2014 Apr 11.