PMID- 24843406
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 2040-1116 (Print)
IS  - 2040-1124 (Electronic)
IS  - 2040-1116 (Linking)
VI  - 1
IP  - 1-2
DP  - 2010 Apr 22
TI  - Sulfonylurea action re-revisited.
PG  - 37-9
LID - 10.1111/j.2040-1124.2010.00014.x [doi]
AB  - Sulfonylureas (SU), commonly used in the treatment of type 2 diabetes mellitus 
      (T2DM), stimulate insulin secretion by inhibiting adenosine triphosphate 
      (ATP)-sensitive K(+) (KATP) channels in pancreatic beta-cells. SU are now known to 
      also activate cyclic adenosine monophosphate (cAMP) sensor Epac2 (cAMP-GEFII) to 
      Rap1 signaling, which promotes insulin secretion. The different effects of 
      various SU on Epac2/Rap1 signaling, as well as KATP channels in different 
      tissues, underlie the diverse pancreatic and extra-pancreatic actions of SU. (J 
      Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00014.x, 2010).
FAU - Seino, Susumu
AU  - Seino S
AD  - Division of Cellular and Molecular Medicine, Department of Physiology and Cell 
      Biology ; Division of Diabetes, Metabolism and Endocrinology, Department of 
      Internal Medicine, Kobe University Graduate School of Medicine, Kobe ; Core 
      Research for Evolutional Science and Technology (CREST), Japan Science and 
      Technology Agency, Saitama.
FAU - Zhang, Chang-Liang
AU  - Zhang CL
AD  - Division of Cellular and Molecular Medicine, Department of Physiology and Cell 
      Biology ; Department of Neurology, Kyoto University Graduate School of Medicine, 
      Kyoto, Japan.
FAU - Shibasaki, Tadao
AU  - Shibasaki T
AD  - Division of Cellular and Molecular Medicine, Department of Physiology and Cell 
      Biology.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Diabetes Investig
JT  - Journal of diabetes investigation
JID - 101520702
PMC - PMC4020675
EDAT- 2010/04/22 00:00
MHDA- 2010/04/22 00:01
PMCR- 2010/04/22
CRDT- 2014/05/21 06:00
PHST- 2014/05/21 06:00 [entrez]
PHST- 2010/04/22 00:00 [pubmed]
PHST- 2010/04/22 00:01 [medline]
PHST- 2010/04/22 00:00 [pmc-release]
AID - JDI14 [pii]
AID - 10.1111/j.2040-1124.2010.00014.x [doi]
PST - ppublish
SO  - J Diabetes Investig. 2010 Apr 22;1(1-2):37-9. doi: 
      10.1111/j.2040-1124.2010.00014.x.